p-Ethynylphenylalanine hydrochloride|188640-63-3|(4-Ethynyl-L-phenylalanine hydrochloride)-陌孚医药/Medlife

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p-Ethynylphenylalanine hydrochloride (Synonyms: 4-Ethynyl-L-phenylalanine hydrochloride)

目录号: PL12478 纯度: ≥99%

CAS No. :188640-63-3

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中文名称	p-Ethynylphenylalanine hydrochloride
英文名称	p-Ethynylphenylalanine hydrochloride
英文别名	4-ethynyl-l-phenylalanine hydrochloride;H-Phe(4-Eth)-OH.HCl;4-Ethynyl-L-phenylalanine HCl;(S)-2-Amino-3-(4-ethynylphenyl)propanoic acid hydrochloride;p-Ethynylphenylalanine hydrochloride
Cas No.	188640-63-3
分子式	C₁₁H₁₂ClNO₂
分子量	225.67
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine hydrochloride) 是一种高效、选择性的，可逆、竞争性的色氨酸羟化酶 (TPH) 抑制剂，其 K_i 值为 32.6 μM。
生物活性	p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine hydrochloride) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a K i of 32.6 μM.
性状	Solid
IC50 & Target[1][2]	Ki: 32.6 μM (TPH)
体外研究(In Vitro)	p-Ethynylphenylalanine hydrochloride selectively and reversibly inhibits the biosynthesis of serotonin. p-Ethynylphenylalanine hydrochloride has a low affinity for various recombinant 5-HT receptors (5-HT1, 5-HT2, 5-HT4, 5-HT5, 5-HT6, and 5-HT7). has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	p-Ethynylphenylalanine hydrochloride (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue. p-Ethynylphenylalanine hydrochloride does not inhibit the aromatic amino acid decarboxylase. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Stokes AH, et al. p-ethynylphenylalanine: a potent inhibitor of tryptophan hydroxylase. J Neurochem. 2000 May;74(5):2067-73.

溶解度数据	In Vitro: DMSO : 50 mg/mL (221.56 mM; ultrasonic and warming and heat to 60°C)H₂O : 12.5 mg/mL (55.39 mM; Need ultrasonic)配制储备液

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