TAS-103 dihydrochloride|174634-09-4|-陌孚医药/Medlife

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TAS-103 dihydrochloride

目录号: PL12370 纯度: ≥98%

CAS No. :174634-09-4

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中文名称	TAS-103 dihydrochloride
中文别名	6-[[2-(二甲基氨基)乙基]氨基]-3-羟基-7H-茚并[2,1-C]喹啉-7-酮二盐酸盐;Tas-103(2盐酸盐)
英文名称	TAS-103 dihydrochloride
英文别名	6-[2-(Dimethylamino)ethylamino]-3-hydroxy-7H-indeno[2,1-c]quinolin-7-one dihydrochloride;BMS-247615;TAS-103;6-{[2-(dimethylamino)ethyl]amino}-3H-indeno[2,1-c]quinoline-3,7(5H)-dione dihydrochloride;6-[2-(dimethylamino)ethylamino]-5H-indeno[2,1-c]quinoline-3,7-dione,dihydrochloride;TAS103 dihydrochloride;BMS247615 dihydrochloride;BMS-247615 dihydrochloride;TAS 103;TAS-103(2HCl);BMS-247615-2HCl;TAS-103(BMS-247615);TAS-103 (dihydrochloride);6-[[2-(Dimethylamino)ethyl]amino]-3-hydroxy-7H-indeno[2,1-c]quinolin-7-one dihydrochloride;BMS 247615 dihydrochloride;1X260YUP2P;6-((2-(dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno(2,1-c)quinolin-7-one dihydrochloride;6-((2-(dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno[2,1-c]quinolin-7-one dihydrochloride;7H-indeno[2,1-c]quinolin-7-one, 6-[[2-(dimethylamino)ethyl]amino]-3-hydroxy-, dihydrochloride;7H-Indeno(2,1-c)quinolin-7-one, 6-((2-(dimethylamino)ethyl)amino)-3-hydroxy-;TAS-103 dihydrochloride
Cas No.	174634-09-4
分子式	C₂₀H₂₁Cl₂N₃O₂
分子量	406.31
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	TAS-103 dihydrochloride 是一种 DNA 拓扑异构酶 I/II (topoisomerase I/II) 双重抑制剂，可用于癌症研究。
生物活性	TAS-103 dihydrochloride is a dual inhibitor of DNA topoisomerase I/II, used for cancer research.
性状	Solid
IC50 & Target[1][2]	Topoisomerase I Topoisomerase II
体外研究(In Vitro)	TAS-103 is a dual inhibitor of DNA topoisomerase I/II. TAS-103 (0.1-10 μM) is active on CCRF-CEM cells, with an IC50 value of 5 nM. TAS-103 (0.1 μM) significantly increases levels of topo IIα FITC immunofluorescence in individual CCRF-CEM cells. TAS-103 (0.01-1 μM) is highly cytotoxic to Lewis lung carcinoma (LLC) cells, and Liposomal TAS-103 is almost as active as free TAS-103. TAS-103 inhibits the viability of HeLa cells, with an IC50 of 40 nM. TAS-103 (10 μM) disrupts signal recognition particle (SRP) complex formation, and induces destabilization of SRP14 and SRP19 and its eventual degradation. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	TAS-103 (30 mg/kg, i.v.) causes significant tumor growth suppression in mice bearing Lewis lung carcinoma (LLC) cells, without obvious body weight loss, and the liposomal TAS-103 is more active than free TAS-103. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Padget K, et al. An investigation into the formation of N- [2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) and 6-[2-(dimethylamino)ethylamino]- 3-hydroxy-7H-indeno[2, 1-C]quinolin-7-one dihydrochloride (TAS-103) stabilised DNA topoisomerase I and II [2]. Shimizu K, et al. Cancer chemotherapy by liposomal 6-[12-(dimethylamino)ethyl]aminol-3-hydroxy-7H-indeno[2,1-clquinolin-7-one dihydrochloride (TAS-103), a novel anti-cancer agent. Biol Pharm Bull. 2002 Oct;25(10):1385-7.

溶解度数据	In Vitro: H₂O : 5 mg/mL (12.31 mM; ultrasonic and warming and heat to 60°C)配制储备液

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