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产品总数：60957
| 中文名称 |
Indimitecan
|
|---|---|
| 中文别名 |
INDIMITECAN
|
| 英文名称 |
Indimitecan
|
| 英文别名 |
INDIMITECAN;V5T7S4HP8A;LMP776;SB16794;Q27291563;6-[3-(1H-Imidazol-1-yl)propyl]-2,3-dimethoxy-5H-[1,3]dioxolo[4′,5′:5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione (ACI);Indimitecan;LMP 776;NSC 725776
|
| Cas No. |
915360-05-3
|
| 分子式 |
C25H21N3O6
|
| 分子量 |
459.45
|
| 包装储存 |
Powder -20°C 3 years；4°C 2 years
|
| 产品详情 |
Indimitecan (LMP776) 是一种拓扑异构酶 I (Top1) 抑制剂，具有抗癌活性。
|
|---|---|
| 生物活性 |
Indimitecan (LMP776) is a topoisomerase I (Top1) inhibitor with anticancer activities.
|
| 性状 |
Solid
|
| IC50 & Target[1][2] |
Top1
|
| 体外研究(In Vitro) |
Indimitecan (LMP776) (0-100 μM) shows antiproliferative potencies against various human cancer cell lines, with mean-graph midpoint (MGM) of 0.079 ± 0.023 μM.Indimitecan shows potent DNA cleavage due to Top1 inhibition.Indimitecan can be substrates for metabolic ketone reductases. has not independently confirmed the accuracy of these methods. They are for reference only.Cell Proliferation Assay
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
|
| 储存方式 |
Powder -20°C 3 years；4°C 2 years
|
| ClinicalTrial |
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| 参考文献 |
[1]. Cinelli MA, et al. Identification, synthesis, and biological evaluation of metabolites of the experimental cancer treatment drugs indotecan (LMP400) and indimitecan (LMP776) and investigation of isomerically hydroxylated indenoisoquinoline analogues as to
|
| 溶解度数据 |
In Vitro: DMSO : 8.33 mg/mL (18.13 mM; ultrasonic and warming and adjust pH to 3 with HCl and heat to 60°C)配制储备液
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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。
2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。
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