Belotecan hydrochloride|213819-48-8|-陌孚医药/Medlife

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Belotecan hydrochloride

目录号: PL12377 纯度: ≥98%

CAS No. :213819-48-8

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中文名称	Belotecan hydrochloride
中文别名	CKD-602 盐酸盐;(S)-4-乙基-4-羟基-11-[2-(异丙基氨基)乙基]-3,4,12,14-四氢-1H-吡喃并[3',4':6,7]氮茚并[1,2-b]喹啉-3,14-二酮盐酸盐;艾拉普林;(S)-4-乙基-4-羟基-11-[2-(异丙基氨基)乙基]-3,4,12,14-四氢-1H-吡喃并[3',4':6,7]中氮茚并[1,2-b]喹啉-3,14-二酮盐酸盐;盐酸贝洛替康
英文名称	Belotecan hydrochloride
英文别名	Camtobell hydrochloride;(S)-4-Ethyl-4-hydroxy-11-[2-(isopropylamino)ethyl]-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione hydrochloride;Belotecan Hydrochloride;CKD-602;Belotecan HCl;CKD 602;Belotecan (hydrochloride);01DZ4127G7;Belotecan hydrochloride (USAN);Belotecan Hydrochloride [USAN];BCP28717;API0009359;D03225;819C488;7-(2-(N;Belotecan hydrochloride
Cas No.	213819-48-8
分子式	C₂₅H₂₈ClN₃O₄
分子量	469.96
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情

Belotecan hydrochloride (CKD-602 hydrochloride) 是拓扑异构酶 I (Topoisomerase I) 抑制剂，是一种合成的喜树碱衍生物。

生物活性

Belotecan hydrochloride (CKD-602 hydrochloride), a Topoisomerase I inhibitor, is a synthetic camptothecin derivative.

性状

Solid

IC50 & Target[1][2]

Top1

体外研究(In Vitro)

Belotecan exerts a significant cytotoxic effect on YD-8, YD-9 and YD-38 cells in a time- and dose-dependent manner with IC50 values of 2.4, 0.18 and 0.05 μg/mL at 72 h following treatment. Belotecan induces apoptosis in these cell lines. Belotecan induces G2/M phase arrest in oral squamous cell cancer cells. Belotecan shows a significant anticancer effect on glioma cells, with IC50 values of 9.07 nM for LN229, 14.57 nM for U251 MG, 29.13 nM for U343 MG, and 84.66 nM for U87 MG. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Belotecan has a significant effect on intracerebral glioma growth, with animals having significantly smaller tumors than those in the control group. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. Kim YK, et al. Anticancer effects of CKD-602 (Camtobell?) via G2/M phase arrest in oral squamous cell carcinoma cell lines. Oncol Lett. 2015 Jan;9(1):136-142.
[2]. Kim YY, et al. CKD-602, a camptothecin derivative, inhibits proliferation and induces apoptosis in glioma cell lines. Oncol Rep. 2009 Jun;21(6):1413-9.

溶解度数据	In Vitro: DMSO : 12.5 mg/mL (26.60 mM; ultrasonic and warming and heat to 60°C)配制储备液

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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