Namitecan|372105-27-6|-陌孚医药/Medlife

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Namitecan

目录号: PL12362 纯度: ≥99%

CAS No. :372105-27-6

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中文名称	Namitecan
英文名称	Namitecan
英文别名	naMitecan;Namitecan
Cas No.	372105-27-6
分子式	C₂₃H₂₂N₄O₅
分子量	434.44
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情

Namitecan 是一种 topoisomerase I 抑制剂，具有抗肿瘤活性。

生物活性

Namitecan is a potent topoisomerase I inhibitor, with antitumor property.

性状

Solid

IC50 & Target[1][2]

Topoisomerase I

体外研究(In Vitro)

Namitecan and cetuximab cooperate in inhibiting EGFR expression. Namitecan induces a dose-dependent decrease in EGFR expression in the different cell lines. ST1968 induces a comparable level of apoptosis in A431 and A431/TPT cells with IC50 of 0.21 and 0.29 μM. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Namitecan (10 mg/kg) in combination with cetuximab (1 mg/mouse) induces synergistic antitumor effects in SCC models as a function of EGFR gene copy number. ST1968 (25 mg/kg) causes acceptable body weight loss and no toxic deaths. ST1968 produces a 100% complete response rate in the mice bearing the A431 tumor, and retains a relevant activity in the topotecan-resistant tumor. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. De Cesare M, et al. Synergistic antitumor activity of cetuximab and namitecan in human squamous cell carcinoma models relies on cooperative inhibition of EGFR expression and depends on high EGFR gene copy number. Clin Cancer Res. 2014 Feb 15;20(4):995-100
[2]. Zuco V, et al. Efficacy of ST1968 (namitecan) on a topotecan-resistant squamous cell carcinoma. Biochem Pharmacol. 2010 Feb 15;79(4):535-41.

溶解度数据	In Vitro: DMSO : 250 mg/mL (575.45 mM; Need ultrasonic)配制储备液

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Data Sheet

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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