LMP744 hydrochloride|308246-57-3|-陌孚医药/Medlife

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LMP744 hydrochloride

目录号: PL12372 纯度: ≥99%

CAS No. :308246-57-3

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中文名称	LMP744 hydrochloride
英文名称	LMP744 hydrochloride
英文别名	LMP744 hydrochloride;NSC706744;LMP744 HCl;230KX4E61B;NSC706744 hydrochloride;BCP34016;Q2;LMP-744 hydrochloride
Cas No.	308246-57-3
分子式	C₂₄H₂₅ClN₂O₇
分子量	488.92
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情

LMP744 hydrochloride (MJ-III65 hydrochloride) 是一种 DNA 嵌和剂，是拓扑异构酶 1 (Top1) 抑制剂，具有抗肿瘤活性。

生物活性

LMP744 hydrochloride (MJ-III65 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity.

性状

Solid

IC50 & Target[1][2]

Top1

体外研究(In Vitro)

The GI50 value of LMP744 (MJ-III-65) for NCI60 cells is 0.1 μM.
LMP744 (0.1-5 μM, 3 days) induces dose-dependent accumulation of cells in the S and G2 phases of the cell cycle. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

LMP744 (MJ-III-65) (10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against human A253 and FaDu tumor xenografts without significant toxicity. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. Antony S, et al. Cellular topoisomerase I inhibition and antiproliferative activity by MJ-III-65 (NSC 706744), an indenoisoquinoline topoisomerase I poison. Mol Pharmacol. 2005 Feb;67(2):523-30.
[2]. Antony S, et al. Bisindenoisoquinoline bis-1,3-{( 5,6-dihydro-5,11-diketo-11H-indeno [1,2-c]isoquinoline)-6-propylamino}propane bis(trifluoroacetate) (NSC 727357), a DNA intercalator and topoisomerase inhibitor with antitumor activity. Mol Pharmacol. 2006

溶解度数据	In Vitro: DMSO : 105 mg/mL (214.76 mM; Need ultrasonic)配制储备液

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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