AMTB hydrochloride|926023-82-7|-陌孚医药/Medlife

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AMTB hydrochloride

目录号: PL12436 纯度: ≥99%

CAS No. :926023-82-7

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中文名称	AMTB hydrochloride
英文名称	AMTB hydrochloride
英文别名	AMTB hydrochloride;N-(3-AMINOPROPYL)-2-[(3-METHYLPHENYL)METHOXY]-N-(2-THIENYLMETHYL)BENZAMIDE HYDROCHLORIDE;AMTB
Cas No.	926023-82-7
分子式	C₂₃H₂₇ClN₂O₂S
分子量	430.99
包装储存	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

产品详情	AMTB hydrochloride 是一种选择性 TRPM8 通道阻滞剂。AMTB hydrochloride 抑制 icilin诱导的 TRPM8 通道激活，pIC₅₀ 为 6.23。AMTB hydrochloride 可用于膀胱过度活动和膀胱疼痛综合征的研究。AMTB hydrochloride 是电压门控钠通道的非选择性抑制剂 (Na_V)。
生物活性	AMTB hydrochloride is a selective TRPM8 channel blocker. AMTB hydrochloride inhibits icilin-induced TRPM8 channel activation with a pIC 50 of 6.23. AMTB hydrochloride can be used for the research of the overactive bladder and painful bladder syndrome. AMTB hydrochloride is a non-selective inhibitor of voltage-gated sodium channels (Na V ).
性状	Solid
体外研究(In Vitro)	AMTB hydrochloride blocks veratridine-induced membrane potential changes at each NaV1 isoform (pIC50s ranging 4.83-5.69 for NaV1.1- NaV1.8). AMTB hydrochloride decreases viable cell number in MDA-MB-231 and SK-BR-3 breast cancer cell lines (30 and 100 μM), and also reduces the migration of MDA-MB-231 cells (30 μM). has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	In the anesthetized rat, AMTB (3 mg/kg; intravenous) hydrochloride decreases the frequency of volume-induced bladder contractions, without reducing the amplitude of contraction. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献	[1]. Lashinger ES, et al. AMTB, a TRPM8 channel blocker: evidence in rats for activity in overactive bladder and painful bladder syndrome. Am J Physiol Renal Physiol. 2008;295(3):F803-F810. [2]. Yapa KTDS, et al. Assessment of the TRPM8 inhibitor AMTB in breast cancer cells and its identification as an inhibitor of voltage gated sodium channels. Life Sci. 2018;198:128-135.

溶解度数据	In Vitro: DMSO : 100 mg/mL (232.02 mM; Need ultrasonic)配制储备液

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