Felypressin|56-59-7|(苯赖加压素; PLV-2)-陌孚医药/Medlife

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Felypressin (Synonyms: 苯赖加压素; PLV-2)

目录号: PL12522

CAS No. :56-59-7

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中文名称	Felypressin
中文别名	苯赖加压素;2-苯丙氨酸-8-赖氨酸加压素;苯赖加压素 Felypressin;苯赖加压素 EP标准品;苯赖加压素 Felypressin;苯赖加压素杂质;醋酸苯赖加压素;胰泌素
英文名称	Felypressin
英文别名	felypressin;2-L-PHENYLALANINE-8-L-LYSINE-VASOPRESSIN;Boc-ala-nh2;Felypressin Acetate;(2-L-Phenylalanine)-8-lysinevasopressin;[PHE2,LYS8]-VASOPRESSIN;2-(phenylalanine)-8-lyine vasopression;2-(Phenylalanine)-8-lysine vasopressin;M.W. 1040.22 C46H65N13O11S2;Octapressin;Phelypressin;PLV-2;N-[5-Amino-1-(carbamoylmethylcarbamoyl)pentyl]-1-[19-amino-13,16-dibenzyl-10-(2-carbamoylethyl)-7-(carbamoylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14;N-[5-Amino-1-(carbamoylmethylcarbamoyl)pentyl]-1-[19-amino-13,16-dibenzyl-10-(2-carbamoylethyl)-7-(carbamoylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide;Felypressinum;Felypressine;Felipresina;2-(L-Phenylalanine)-8-L-lysinevasopressin;Phe(2)-Lys(8)-vasopressin;17N2918V6G;Felipressina [DCIT];Felipresina [INN-Spanish];Felypressinum [INN-Latin];Felypressine [INN-French];L-Cysteinyl-L-phenylalanyl-L-phenylalanyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-lysylglycinamide cyclic (1-6)disulfide;Felypressin [USAN:INN:BAN];C46-H65-N13-O11-S2;NCGC00182033-01;EINECS 200-282-7;Felipressina;CHEMBL3185126;CHEBI:60564;H-[Cys-Phe-Phe-Gln-Asn-Cys]-Pro-Lys-Gly-NH2;DTXSID6048599;C46H65N13O11S2;56-59-7;2-(phenylalanine)-8-lysine vasopressin;1-{[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13,16-dibenzyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-L-prolyl-L-lysylglycinamide;SCHEMBL33291;CAS-56-59-7;Vasopressin, 2-L-phenylalanine-8-L-lysine-;DTXCID6028525;(S)-N-((S)-6-amino-1-((2-amino-2-oxoethyl)amino)-1-oxohexan-2-yl)-1-((4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13,16-dibenzyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carbonyl)pyrrolidine-2-carboxamide;(2S)-N-[(2S)-6-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxohexan-2-yl]-1-[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13,16-dibenzyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide;Tox21_112932;FELYPRESSIN;HY-A0182;Octopressin;A913370;Felypressin [USAN:BAN:INN];DB00093;UNII-17N2918V6G;CS-5837;Felypressin
Cas No.	56-59-7
分子式	C₄₆H₆₅N₁₃O₁₁S₂
分子量	1040.22
包装储存	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

产品详情

Felypressin (PLV-2) 是一种非儿茶酚胺的血管收缩剂，也是一种加压素 1 (vasopressin 1) 激动剂。Felypressin 广泛用于牙科手术中。

生物活性

Felypressin (PLV-2) is a non-catecholamine vasoconstrictor and a vasopressin 1 agonist. Felypressin is widely used in dental procedures.

性状

Solid

IC50 & Target[1][2]

Vasopressin 1

体外研究(In Vitro)

Felypressin is a synthetic hormone of the posterior pituitary lobe characterized by vasoconstrictor properties that is widely used in dental procedures. The vasoconstrictor action of Felypressin seems to be mediated by V1 receptors of the blood vessel smooth muscle cells. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Felypressin can reduce toxicity during dental procedures. Felypressin increases the diastolic blood pressure of hypertensive patients with controlled blood pressure.
Cardiovascular effects of Felypressin (240 ng/kg; intravenous injection) are studied in Wistar rats. Felypressin induces a pressor effect. Felypressin depends on V1 receptors to induce pressor and bradycardic effects, and that it produces a high relationship between bradycardia and mean arterial pressure variation depending on area postrema and central V1 receptors. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

ClinicalTrial

SequenceShortening

CFFQNCPKG-NH2 (Disulfide bridge: Cys1-Cys6)

Sequence

Cys-Phe-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 (Disulfide bridge: Cys1-Cys6)

参考文献

[1]. Bronzo AL et al. Felypressin increases blood pressure during dental procedures in hypertensive patients. Arq Bras Cardiol. 2012 Aug;99(2):724-31.
[2]. Cecanho R et al. Cardiovascular effects of felypressin. Anesth Prog. 2006 Winter;53(4):119-25.

溶解度数据	In Vitro: DMSO : ≥ 10.4 mg/mL (10.00 mM)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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