AZ-23|915720-21-7|(AZ23; AZ 23)-陌孚医药/Medlife

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AZ-23 (Synonyms: AZ23; AZ 23)

目录号: PL12412 纯度: ≥98%

CAS No. :915720-21-7

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中文名称	AZ-23
中文别名	5-氯-N-[(1S)-1-(5-氟吡啶-2-基)乙基]-N''-(5-异丙氧基-1H-吡唑-3-基)嘧啶-2,4-二胺;5-氯-N-[(1S)-1-(5-氟吡啶-2-基)乙基]-N'-(5-异丙氧基-1H-吡唑-3-基)嘧啶-2,4-二胺;5-氯-N-[(1S)-1-(5-氟吡啶-2-基)乙基]-N-(5-异丙氧基-1H-吡唑-3-基)嘧啶-2,4-二胺
英文名称	AZ-23
英文别名	AZ-23;5-chloro-2-N-[(1S)-1-(5-fluoropyridin-2-yl)ethyl]-4-N-(3-propan-2-yloxy-1H-pyrazol-5-yl)pyrimidine-2,4-diamine;AZ 23;5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyridinyl)ethyl]-N4-[5-(1-methylethoxy)-1H-pyrazol-3-yl]-2,4-pyrimidinediamine (ACI);5-Chloro-N-[(1S)-1-(5-fluoropyridin-2-yl)ethyl]-N′-(5-isopropoxy-1H-pyrazol-3-yl)pyrimidine-2,4-diamine;AZD 1332;AZD-1332;AZD1332
Cas No.	915720-21-7
分子式	C₁₇H₁₉ClFN₇O
分子量	391.83
包装储存	Powder -20°C 3 years；In solvent -80°C 6 months

产品详情	AZ-23是ATP-竞争型，有口服活性的Trk激酶 A/B/C抑制剂，IC₅₀值分别为2 nM (TrkA)，8 nM (TrkB)，24 nM (FGFR1)，52 nM (Flt3)，55 nM (Ret)，84 nM (MuSk)，99 nM (Lck)。
生物活性	AZ-23 is an ATP-competitive and orally bioavailable Trk kinase A/B/C inhibitor with IC 50 s of 2 nM (TrkA), 8 nM (TrkB), 24 nM (FGFR1), 52 nM (Flt3), 55 nM (Ret), 84 nM (MuSk), 99 nM (Lck), respectively.
性状	Solid
IC50 & Target[1][2]	TrkA 2 nM (IC50) TrkB 8 nM (IC50
体外研究(In Vitro)	AZ-23 potently and selectivity inhibits Trk phosphorylation in cells. AZ-23 potently inhibits Trk-mediated survival (EC50 of 2 nM). AZ-23 Inhibits Trk-Dependent Survival in MCF10ATrkA-Δ and TF-1 Cell Lines. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	AZ-23 shows in vivo TrkA kinase inhibition and efficacy in mice following oral administration in a TrkA-driven allograft model and significant tumor growth inhibition in a Trk-expressing xenograft model of neuroblastoma. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；In solvent -80°C 6 months
参考文献	[1]. Thress K, et al. Identification and preclinical characterization of AZ-23, a novel, selective, and orally bioavailable inhibitor of the Trk kinase pathway. Mol Cancer Ther. 2009 Jul; 8(7):1818-27.

溶解度数据	In Vitro: DMSO : 125 mg/mL (319.02 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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