Pregnenolone-d4-1|61574-54-7|(孕烯醇酮-d-陌孚医药/Medlife

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Pregnenolone-d4-1 (Synonyms: 孕烯醇酮-d

目录号: PL12460 纯度: ≥98.0%

CAS No. :61574-54-7

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中文名称	Pregnenolone-d4-1
中文别名	孕烯醇酮-4;妊娠烯醇酮-D4;妊娠烯醇酮-D4氘代内标
英文名称	Pregnenolone-d4-1
英文别名	PREGNENOLONE-17ALPHA,21,21,21-D4;Pregnenolone-d4;(+/-)-1,2:4,5-di-O-cyclohexylidene-myo-inositol;(D-2-Chloracetamino-4-methyl-valerylamino)-essigsa;1,2:4,5-Biscyclohexylidene DL-myo-Inositol;1,2:4,5-dicyclohexylidene-myo-inositol;1,2:4,5-di-O,O-cyclohexylidene-myo-inositol;1,2:4,5-Di-O-cyclohexylidene-D,L-myo-inositol;17,21,21,21-d4-pregnenolone;AGN-PC-00MN25;N-(N-Chloracetyl-D-leucyl)-glycin;N-(N-chloroacetyl-D-leucyl)-glycine;Pregnenolone-d4-1;Pregnenolone-d
Cas No.	61574-54-7
分子式	C₂₁H₃₂O₂
分子量	316.48
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	Pregnenolone-d₄-1 是一种氘代标记的 Pregnenolone。Pregnenolone (3β-Hydroxy-5-pregnen-20-one) 是一种功能强大的神经甾体，是包括甾体酮在内的各种甾体激素的主要前体。Pregnenolone 是大麻素 CB1 受体的信号传导特异性抑制剂，抑制由 CB1 受体介导的四氢大麻酚 (THC) 的作用。Pregnenolone 可以保护大脑免受大麻中毒。Pregnenolone 也是一种 TRPM3 通道激活剂，也可以弱激活 TRPM1 通道。
生物活性	Pregnenolone-d 4 -1 is the deuterium labeled Pregnenolone. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication[1][2]. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels[3].
性状	Solid
体外研究(In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Vallée M, et al. Pregnenolone can protect the brain from cannabis intoxication. Science. 2014 Jan 3;343(6166):94-8. [3]. Ducharme N, et al. Brain distribution and behavioral

溶解度数据	In Vitro: DMSO : 31.25 mg/mL (97.50 mM; ultrasonic and warming and heat to 60°C)配制储备液

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