Garenoxacin Mesylate hydrate|223652-90-2|(加雷沙星甲磺酸盐; BMS284756 Mesylate hydrate)-陌孚医药/Medlife

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Garenoxacin Mesylate hydrate (Synonyms: 加雷沙星甲磺酸盐; BMS284756 Mesylate hydrate)

目录号: PL12393 纯度: ≥99%

CAS No. :223652-90-2

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中文名称	Garenoxacin Mesylate hydrate
中文别名	甲磺酸加雷沙星一水合物;1-环丙基-8-(二氟甲氧基)-7-[(1R)-2,3-二氢-1-甲基-1H-异吲哚-5-基]-1,4-二氢-4-氧代-3-喹啉甲酸甲磺酸盐一水合物;甲磺酸加雷沙星;甲磺酸加雷沙星杂质对照品;加雷沙星甲磺酸盐
英文名称	Garenoxacin Mesylate hydrate
英文别名	Garenoxacin mesylate hydrate;1-Cyclopropyl-8-(difluoromethoxy)-7-[(1R)-2,3-dihydro-1-methyl-1H-isoindol-5-yl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid methanesulfonate hydrate;1-cyclopropyl-8-(difluoromethoxy)-7-[(1R)-1-methyl-2,3-dihydro-1H-isoindol-5-yl]-4-oxoquinoline-3-carboxylic acid,methanesulfonic acid,hydrate;Garenoxacin (Mesylate hydrate);GARENOXACIN MESYLATE;1-cyclopropyl-8-(difluoromethoxy)-7-[(1R)-1-methyl-2,3-dihydro-1H-5-isoindolyl]-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid methanesulfonate monohydrate;Garenoxacin mesilate;Geninax;Inforce;1-Cyclopropyl-8-(difluoromethoxy)-7-[(1R)-2,3-dihydro-1-methyl-1H-isoindol-5-yl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid methane sulfonic acid salt monohydrate;BMS 284756 mesylate;Ganefloxacin mesylate;Garenfloxacin mesylate;T-3811 mesylate;Garenoxacin;BMS284756 Mesylate hydrate;Garenoxacin Mesylate hydrate
Cas No.	223652-90-2
分子式	C₂₃H₂₀N₂O₄F₂^.CH₄O₃S^.H₂O
分子量	540.53
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	Garenoxacin (BMS284756) Mesylate hydrate 是一种具有口服活性的喹诺酮类抗生素 (antibiotic)，对各种革兰氏阳性和革兰氏阴性细菌、厌氧菌和复养微生物具有广泛的活性。
生物活性	Garenoxacin (BMS284756) Mesylate hydrate is an orally active quinolone antibiotic and has a broad spectrum of activity against a wide array of gram-positive and gram-negative bacteria, anaerobes, and fastidious organisms.
性状	Solid
IC50 & Target[1][2]	Quinolone Gyrase 1.25 μg/mL (IC50)
体外研究(In Vitro)	Garenoxacin (BMS284756) (0-8 days) inhibits mycoplasmas and ureaplasmas with MIC90s ≤0.25 μg/mL against tested strains. Garenoxacin (48 h) inhibits S. aureus wild type and mutants with MICs of 0.0128-4.0 μg/mL. Garenoxacin inhibits topoisomerase IV and gyrase from S. aureus with IC50s of 1.25 to 2.5 and 1.25 μg/mL, respectively. Garenoxacin has a low propensity for selective enrichment of fluoroquinolone-resistant mutants among ciprofloxacin-susceptible isolates of S. aureus . has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Garenoxacin (12.5-50 mg/kg; s.c.; once) is highly effective against the wild-type strain and mutants harboring a single mutation in a mouse pneumonia model with S. pneumonia infection. Garenoxacin (10 and 30 mg/kg; p.o.; once) reduces the viable cell counts in the lungs and significantly prolongs survival on experimental secondary pneumococcal pneumonia caused by S. pneumoniae D-979 in BALB/c female mice. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Waites KB, et al. In vitro susceptibilities to and bactericidal activities of garenoxacin (BMS-284756) and other antimicrobial agents against human mycoplasmas and ureaplasmas. Antimicrob Agents Chemother. 2003 Jan;47(1):161-5. [2]. Ince D, et al. Dual targeting of DNA gyrase and topoisomerase IV: target interactions of garenoxacin (BMS-284756, T-3811ME), a new desfluoroquinolone. Antimicrob Agents Chemother. 2002 Nov;46(11):3370-80.

溶解度数据	In Vitro: DMSO : 100 mg/mL (185.00 mM; Need ultrasonic)H₂O : 12.5 mg/mL (23.13 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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