WEHI-9625|2595314-46-6|-陌孚医药/Medlife

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WEHI-9625

目录号: PL12565 纯度: ≥99%

CAS No. :2595314-46-6

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产品详情	WEHI-9625 是一种首创的，三环砜小分子凋亡抑制剂，EC₅₀ 值为 69 nM。WEHI-9625 与 VDAC2 结合可促进其抑制小鼠 BAK 诱导的细胞凋亡的能力，但对人 BAK 和与凋亡效应密切相关的 BAX 因子均完全无效。
生物活性	WEHI-9625 is a tricyclic sulfone, first-in-class inhibitor of apoptosis with an EC 50 of 69 nM. WEHI-9625 binds to VDAC2 and promotes its ability to inhibit apoptosis driven by mouse BAK. WEHI-9625 is completely inactive against both human BAK and the closely related apoptosis effector BAX.
性状	Solid
IC50 & Target[1][2]	Bak Bax
体外研究(In Vitro)	WEHI-9625 (0-10 μM; Mcl1Bax MEFs cells) treatment could prevent cell death mediated by BAK and potently inhibits BIM BH3-induced loss of mitochondrial membrane potential in Bax, but not Bak, cells. has not independently confirmed the accuracy of these methods. They are for reference only.Cell Viability Assay-tbl">
体内研究(In Vivo)	WEHI-9625 demonstrates that blocking apoptosis at an early stage was both advantageous and pharmacologically tractable. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. van Delft MF, et al. A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis. Nat Chem Biol. 2019 Oct 7.

溶解度数据	In Vitro: DMSO : 100 mg/mL (168.43 mM; Need ultrasonic)配制储备液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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