Nalidixic Acid-d5|1189467-36-4|-陌孚医药/Medlife

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Nalidixic Acid-d5

目录号: PL12355

CAS No. :1189467-36-4

商品编号	规格	价格	会员价	是否有货	数量
PL12355-1mg	1mg	询价	询价
PL12355-10mg	10mg	询价	询价

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中文名称	Nalidixic Acid-d5
中文别名	萘啶酸-D5标准品;3,5-二甲氧基苯甲酸;WITEGACH003萘啶酸-D5标准品;氘代萘啶酸-D5 标准品;萘啶酸;萘啶酸-D5;萘啶酸 d5
英文名称	Nalidixic Acid-d5
英文别名	Nalidixic acid-D5;Nalidixic acid-(ethyl-d5);1,4-Dihydro-1-(ethyl-d5)-7-methyl-1,8-naphthyridin-4-one-3-carboxylic acid;1-(Ethyl-d5)-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid;Nalidixinic acid-d5;Nalidixic acid-(ethyl-d5), VETRANAL(TM), analytical standard;7-methyl-4-oxo-1-(1,1,2,2,2-pentadeuterioethyl)-1,8-naphthyridine-3-carboxylic acid
Cas No.	1189467-36-4
分子式	C₁₂H₁₂N₂O₃
分子量	237.27
包装储存	Please store the product under the recommended conditions in the Certificate of Analysis.

产品详情	Nalidixic Acid-d₅ 是 Nalidixic acid 的氘代物。Nalidixic acid，一种喹诺酮类抗生素 (antibiotic)，对革兰氏阳性和革兰氏阴性细菌均有效。Nalidixic acid 在较低浓度下以抑菌的方式起作用，而在较高浓度下具有杀菌作用。Nalidixic acid 抑制 DNA 促旋酶和拓扑异构酶 IV 的亚基，并可逆地阻止易感细菌中的 DNA 复制。
生物活性	Nalidixic Acid-d 5 is the deuterium labeled Nalidixic acid. Nalidixic acid, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria[1].
体外研究(In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. antibiotic, DNA gyrase, susceptible bacteria, Escherichia coli, Klebsiella pneuiiioniae, Aerobacter aeroyenes, Proteus spp, Salmonella spp. [3]. Anna Fàbrega, et al. Mechanis

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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