Calcitetrol|72203-93-1|(1α, 24, 25-Trihydroxy VD3)-陌孚医药/Medlife

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Calcitetrol (Synonyms: 1α, 24, 25-Trihydroxy VD3)

目录号: PL12550 纯度: ≥99%

CAS No. :72203-93-1

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中文名称	Calcitetrol
中文别名	1ALPHA,24,25-三羟基生素 D3;钙四醇;1alpha,24,25-三羟基維生素 D3
英文名称	Calcitetrol
英文别名	Calcitetrol;(1alpha,24R,25)-trihydroxy-Vitamin D3;1α, 24, 25-Trihydroxy VD3;9,10-Secocholesta-5,7,10(19)-triene-1,3,24,25- tetrol,(1R,3â(1R,3S,5Z)-5-[(2E)-2-[1-[(1R)-4,5-Dihydroxy-1,5-dimethylhexyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-cyclohexanediol;1alpha,24,25-Trihydroxyvitamin D3
Cas No.	72203-93-1
分子式	C₂₇H₄₄O₄
分子量	432.64
包装储存	4°C, protect from light, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

产品详情	Calcitetrol(1α, 24, 25-Trihydroxy VD3)是含3个羟基的维生素D活性形式。
生物活性	Calcitetrol(1α, 24, 25-Trihydroxy VD3) is the hormonally active form of vitamin D with three hydroxyl groups. IC50 value: Target: Calcitriol increases blood calcium levels ([Ca2+]) by promoting absorption of dietary calcium from the gastrointestinal tract and increasing renal tubular reabsorption of calcium, thus reducing the loss of calcium in the urine. Calcitriol also stimulates release of calcium from bone by its action on the specific type of bone cells referred to as osteoblasts, causing them to release RANKL, which in turn activates osteoclasts.
性状	Solid
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, protect from light, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
参考文献	[1]. Johanna A. Huhtakangas, Christopher J. Olivera, June E. Bishop et al. The Vitamin D Receptor Is Present in Caveolae-Enriched Plasma Membranes and Binds 1α,25(OH)2-Vitamin D3in Vivo and in Vitro. Molecular Endocrinology November 1, 2004 vol. 18 no. 11 2660 [2]. Robert A. Parise, Merrill J. Egorin, Beatriz Kanterewicz et al. CYP24, the enzyme that catabolizes the antiproliferative agent vitamin D, is increased in lung cancer. International Journal of Cancer. Volume 119, Issue 8, pages 1819-1828, 15 October 2006

溶解度数据	In Vitro: DMSO : 100 mg/mL (231.14 mM; Need ultrasonic)配制储备液

搜索质检报告(COA)

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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