CU-CPT-9a|2165340-32-7|-陌孚医药/Medlife

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CU-CPT-9a

目录号: PL12344 纯度: ≥99%

CAS No. :2165340-32-7

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中文名称	CU-CPT-9a
英文名称	CU-CPT-9a
英文别名	CU-CPT-9b;4-(7-methoxyquinolin-4-yl)-2-methylphenol;2-Methyl-4-(7-methoxyl-4-quinolinyl)-phenol;Phenol, 4-(7-methoxy-4-quinolinyl)-2-methyl;CU-CPT-9a;CU CPT 9a;2-Methyl-4-(7-methoxy-4-quinolinyl)phenol;4-(7-methoxyquinolin-4-yl)-2-methyl-phenol;CU-CPT9a;AMY16836;BCP29122;s9730;4-(7-Methoxy-4-quinolinyl)-2-methylphenol;AK00779581;4-(7-methoxy-1H-quinolin-4-ylidene)-2-methylcyclohexa-2,5-dien-1-one;7VC
Cas No.	2165340-32-7
分子式	C₁₇H₁₅NO₂
分子量	265.31
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	CU-CPT-9a 是 TLR8 的特异性拮抗剂，其 IC₅₀ 值为 0.5 nM。
生物活性	CU-CPT-9a is a specific TLR8 antagonist, with an IC 50 of 0.5 nM.
性状	Solid
IC50 & Target[1][2]	TLR8 0.5 nM (IC50)
体外研究(In Vitro)	CU-CPT-9a is a specific TLR8 antagonist, with an IC50 of 0.5±0.1 nM. The elevation of the downstream protein levels induced by R848 can be reversed by CU-CPT-9a in a dose-dependent manner. By contrast, the expression of TRIF and IRF3 (cytoplasmic and nuclear) are only responsive to TLR4 and TLR3, independent of TLR837. The expression levels of TRIF and IRF3 do not show significant change in THP-1 cells upon treatment of R848, nor do they change with the treatment of CU-CPT-9a. CU-CPT8m and CU-CPT-9a both significantly suppress the TNF-α level in a dose-dependent manner, which is in agreement with previous reports of TLR8 involvement in these autoimmune diseases. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Zhang S, et al. Small-molecule inhibition of TLR8 through stabilization of its resting state. Nat Chem Biol. 2018 Jan;14(1):58-64.

溶解度数据	In Vitro: DMSO : 135 mg/mL (508.84 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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