Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) 是一种烟酰胺腺嘌呤核苷酸 (NAD⁺) 的代谢产物，也是一种最有效和最主要的细胞内 Ca²⁺ 渗透性阳离子 TRPM2 通道激活剂，还可以增强自噬 (autophagy)。

Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD) metabolite. Adenosine 5′-diphosphoribose sodium is the most potent and primary intracellular Ca-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose sodium also can enhance autophagy.

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TRPM2 channel
Autophagy

In mouse embryonic fibroblasts (MEFs), H2O2 treatment demonstrates that the activation of poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) produced Adenosine 5′-diphosphoribose (ADP ribose), which is an activating signal for TRPM2 channels, thereby promoting Ca elevation through extracellular Ca influx and (or) lysosomal Ca release. This process eventually activates early or late autophagy in response to different degrees of oxidative stress.
TRPM2 channels are activated by binding of Adenosine 5′-diphosphoribose (ADP ribose) to the intracellular NUDT9-homology (NUDT9-H) domain unique to TRPM2 and located at its C terminus. In addition to ADPR, intracellular Ca is an essential coactivator: TRPM2 channels open only in the combined presence of both ligands. has not independently confirmed the accurac

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

[1]. Zhang DX, et al. The potential regulatory roles of NAD(+) and its metabolism in autophagy. Metabolism. 2016 Apr;65(4):454-62.
[2]. Tóth B, et al. Pore collapse underlies irreversible inactivation of TRPM2 cation channel currents. Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13440-5.

In Vitro: H₂O : 125 mg/mL (215.04 mM; Need ultrasonic)DMSO : 25 mg/mL (43.01 mM; ultrasonic and warming and heat to 80°C)配制储备液