TPO agonist 1|1033040-23-1|-陌孚医药/Medlife

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TPO agonist 1

目录号: PL11890 纯度: ≥98.0%

CAS No. :1033040-23-1

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产品详情	TPO agonist 1 是一种 TPO 激动剂，可用作血小板生成和巨核细胞生成的促进剂，可用于血小板减少症的研究。详细信息请参考专利文献 WO2008134338A1 中的化合物 TPO mimetic。
生物活性	TPO agonist 1 is a thrombopoietin (TPO) agonist extracted from patent WO2008134338A1, compound TPO mimetic. It would be useful as promoters of thrombopoiesis and megakaryocytopoiesis to treat thrombocytopenia.
性状	Solid
IC50 & Target[1][2]	TPO receptor
体内研究(In Vivo)	The thrombopoietin (TPO) receptor agonists are novel treatments for patients with chronic ITP aimed at increasing platelet production through interactions with the TPO receptor on megakaryocytes, and can increases platelet counts, decrease bleeding events and reduce the need for adjunctive or rescue treatments. The TPO receptor agonists are well-tolerated, though uncertainty remains regarding the risk of thromboembolism and bone marrow fibrosis. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Jerome Francis Hayes. Novel processes of making hydroxy-1-azo-derivatives as tpo mimetics. 6 November 2008. WO2008134338A1. [2]. Siegal D et al. Thrombopoietin receptor agonists in primary immune thrombocytopenia. et al. Semin Hematol. 2013 Jan;50 Suppl 1:S18-21

溶解度数据	In Vitro: DMSO : ≥ 36 mg/mL (77.17 mM)配制储备液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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