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| 中文名称 |
Hydrochlorothiazid-d2
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|---|---|
| 中文别名 |
氢氯噻嗪-D2氘代内标;[ 2H2] - 氢氯噻嗪标准品;氢氯噻嗪-3,3-d2;氢氯噻嗪-D2;双氢克尿噻-D2;[2H2]-氢氯噻嗪;氢氯噻嗪杂质26;氢氯噻嗪 d2
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| 英文名称 |
Hydrochlorothiazid-d2
|
| 英文别名 |
Hydrochlorothiazide-3,3-d2;Hydrochlorothiazide-d2;HYDROCHLOROTHIAZIDE-3,3-D2;HYDROCHLOROTHIAZIDE-D2;[2H2]-Hydrochlorothiazide;Hydrochlorothiazide D2Q: What is
Hydrochlorothiazide D2 Q: What is the CAS Number of
Hydrochlorothiazide D2 Q: What is the storage condition of
Hydrochlorothiazide D2 Q: What are the applications of
Hydrochlorothiazide D2;Hydrochlorothiazide Impurity 26;Hydrochlorothiazid-d2;Hydrochlorothiazid-d
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| Cas No. |
1219798-89-6
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| 分子式 |
C7H8ClN3O4S2
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| 分子量 |
297.74
|
| 包装储存 |
Powder -20°C 3 years；4°C 2 years
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| 产品详情 |
Hydrochlorothiazid-d2 是 Hydrochlorothiazide 的氘代物。Hydrochlorothiazide (HCTZ) 是一种口服有效的噻嗪类的利尿药，可抑制转化 TGF-β/Smad 信号通路。Hydrochlorothiazide 通过打开钙激活钾 (KCA) 通道具有直接的血管松弛作用。Hydrochlorothiazide 改善心脏功能，减少纤维化并具有降压作用。
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| 生物活性 |
Hydrochlorothiazid-d 2 is the deuterium labeled Hydrochlorothiazide. Hydrochlorothiazide (HCTZ), an orally active diuretic drug of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect[1][2][3].
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| 性状 |
Solid
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| 体外研究(In Vitro) |
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. has not independently confirmed the accuracy of these methods. They are for reference only.
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
Powder -20°C 3 years；4°C 2 years
|
| 参考文献 |
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Duarte, J.D. and R.M. Cooper-DeHoff, Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretics. Expert Rev Cardiovasc Ther, 2010. 8(6): p. 793-802.
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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。
2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。
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