Adalimumab|331731-18-1|(阿达木单抗; Anti-Human TNF-alpha, Human Antibody)-陌孚医药/Medlife

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Adalimumab (Synonyms: 阿达木单抗; Anti-Human TNF-alpha, Human Antibody)

目录号: PL11959 纯度: ≥98%

CAS No. :331731-18-1

商品编号	规格	价格	会员价
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PL11959-5mg	5mg	¥7047.27	请登录
PL11959-25mg	25mg	询价	询价
PL11959-50mg	50mg	询价	询价

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中文名称	Adalimumab
中文别名	阿达木单抗
英文名称	Adalimumab
英文别名	Unii-fys6T7F842;Adalimumab;D2E7;Humira;Immunoglobulin G1, anti-(human tumor necrosis factor) (human monoclonal D2E7 heavy chain), disulfide with human monoclonal D2E7 light chain, dimer;D 2E7;Sivelestat;ONO5046;2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetic acid;LY544349;C20H22N2O7S;EI546;N-(2-(4-(2,2-Dimethylpropionyloxy)phenylsulfonylamino)benzoyl)aminoacetic acid;DWI62G0P59;EI546;LY544349;ONO5046;2-(2-(4-(pivaloyloxy)phenylsulfonamido)benzamido)acetic acid;2-[(2-{4-[(2,2-dimethylpropanoyl)oxy]benzenesulfonamido}phenyl)formamido]acetic acid;N-[2-(N'-(Carboxymethyl)-aminocarbonyl)-p
Cas No.	331731-18-1
包装储存	Please store the product under the recommended conditions in the Certificate of Analysis.

产品详情

Adalimumab 是一种人源的单克隆 IgG1 抗体，靶向肿瘤坏死因子α (TNF-α)。

生物活性

Adalimumab is a human monoclonal IgG1 antibody targeting tumour necrosis factor?α (TNF-α).

性状

Liquid

IC50 & Target[1][2]

TNF-α

体外研究(In Vitro)

Treatment of HUVECs with Adalimumab for up to 12 hours shows no adverse effect on their cell viability, even with a 10-fold higher concentration of Adalimumab than used in this study. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

The elimination half-life (t 1/2 ) of Adalimumab is long (~20 days). The enriched fluorescent-labelled adalimumab is observed mainly in major Oil red O-positive lesions documenting good tissue penetration of the drug into the atherosclerotic plaque, without background fluorescence of the vessel wall after vehicle control injection into hypercholesterolemic Ldlr mice. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

ClinicalTrial

参考文献

[1]. Ternant D, et al. Pharmacokinetics and concentration-effect relationship of adalimumab in rheumatoid arthritis. Br J Clin Pharmacol. 2015 Feb;79(2):286-97.
[2]. Oberoi R, et al. Targeting Tumor Necrosis Factor-α with Adalimumab: Effects on Endothelial Activation and Monocyte Adhesion. PLoS One. 2016 Jul 28;11(7):e0160145.

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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