L-Thyroxine sodium salt pentahydrate|6106-07-6|(L-甲状腺素钠五水合物; Sodium levothyroxine pentahydrate)-陌孚医药/Medlife

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L-Thyroxine sodium salt pentahydrate (Synonyms: L-甲状腺素钠五水合物; Sodium levothyroxine pentahydrate)

目录号: PL11900 纯度: ≥99%

CAS No. :6106-07-6

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PL11900-10mM*1mLinDMSO	10mM*1mLinDMSO	¥884.00	请登录

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中文名称	L-Thyroxine sodium salt pentahydrate
中文别名	左旋甲状腺素钠五水合物;O-(4-羟基-3,5-二碘苯基)-3,5-二碘-L-酪氨酸单钠盐五水合物;3',3,5',5-四碘甲腺原氨酸钠盐五水合物;L-甲状腺素;L-甲状腺素钠;L-甲状腺素钠五水物
英文名称	L-Thyroxine sodium salt pentahydrate
英文别名	Sodium levothyroxine pentahydrate;O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine monosodium salt pentahydrate;3',3,5',5-Tetraiodo-L-thyronine sodium salt pentahydrate;L -THYROXINE SODIUM SALT PENTAHYDRATE CRYSTALLINE;L-Thyroxine (sodium salt pentahydrate);sodium,(2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoate,pentahydrate;L-Thyroxine sodium salt pentahydrate
Cas No.	6106-07-6
分子式	C₁₅H₁₀NO₄I₄-^.Na+^.₅[H₂O]
分子量	888.93
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情

L-Thyroxine sodium salt pentahydrate (Levothyroxine; T4) 是一种合成的甲状腺激素，用于甲状腺功能减退症的研究。DIO 酶将 L-Thyroxine (T4) 转化成具有生物活性的三碘甲状腺氨酸 (T3)。

生物活性

L-Thyroxine sodium salt pentahydrate (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4).

性状

Solid

IC50 & Target[1][2]

Human Endogenous Metabolite

体内研究(In Vivo)

Deiodinases (DIOs), which catalyse the conversion of thyroxine (pro-hormone) to the active thyroid hormone, are associated with thyroid stimulating hormone (TSH) levels. DIO1 and DIO2 catalyze activation of thyroid hormone secretion in contrast to DIO3 playing role inactivation of the secretion. Activities of DIO1 and DIO2 play pivotal role in the negative feedback regulation of pituitary TSH secretion. L-Thyroxine (T4) and Triiodothyronine (T3) hormones are known to modulate the expression of ionic channels, pumps and regulatory contractile proteins. Moreover, thyroid hormones have been shown to influence calcium homeostasis and flux responsible for excitation and contractility, with L-Thyroxine and Triiodothyronine modulating its pharmacological control and secretion. In rats fed 12 weeks with the iodine-free diet, a significant decrease in the levels of both Triiodothyronin

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. Arici M, et al. Association between genetic polymorphism and levothyroxine bioavailability in hypothyroid patients. Endocr J. 2018 Mar 28;65(3):317-323.
[2]. Corriveau S, et al. Levothyroxine treatment generates an abnormal uterine contractility patterns in an in vitro animalmodel. J Clin Transl Endocrinol. 2015 Sep 9;2(4):144-149.

溶解度数据	In Vitro: DMSO : ≥ 28 mg/mL (31.50 mM)H₂O : < 0.1 mg/mL (insoluble)

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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