Adalimumab (anti-TNF-α)|331731-18-1|-陌孚医药/Medlife

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Adalimumab (anti-TNF-α)

目录号: PL11955 纯度: ≥99%

CAS No. :331731-18-1

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中文名称	Adalimumab (anti-TNF-α)
中文别名	阿达木单抗
英文名称	Adalimumab (anti-TNF-α)
英文别名	Unii-fys6T7F842;Adalimumab;D2E7;Humira;Immunoglobulin G1, anti-(human tumor necrosis factor) (human monoclonal D2E7 heavy chain), disulfide with human monoclonal D2E7 light chain, dimer;D 2E7;Sivelestat;ONO5046;2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetic acid;LY544349;C20H22N2O7S;EI546;N-(2-(4-(2,2-Dimethylpropionyloxy)phenylsulfonylamino)benzoyl)aminoacetic acid;DWI62G0P59;EI546;LY544349;ONO5046;2-(2-(4-(pivaloyloxy)phenylsulfonamido)benzamido)acetic acid;2-[(2-{4-[(2,2-dimethylpropanoyl)oxy]benzenesulfonamido}phenyl)formamido]acetic acid;N-[2-(N'-(Carboxymethyl)-aminocarbonyl)-p
Cas No.	331731-18-1
包装储存	Please store the product under the recommended conditions in the Certificate of Analysis.

产品详情	Adalimumab (anti-TNF-α) 是一种人源的单克隆 IgG1 抗体，靶向肿瘤坏死因子α (TNF-α)。
生物活性	Adalimumab (anti-TNF-α) is a human monoclonal IgG1 antibody targeting tumour necrosis factor?α (TNF-α).
性状	Liquid
体外研究(In Vitro)	Treatment of HUVECs with Adalimumab for up to 12 hours shows no adverse effect on their cell viability, even with a 10-fold higher concentration of Adalimumab (anti-TNF-α) than used in this study. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	The elimination half-life (t 1/2 ) of Adalimumab (anti-TNF-α) is long (~20 days). The enriched fluorescent-labelled adalimumab (anti-TNF-α) is observed mainly in major Oil red O-positive lesions documenting good tissue penetration of the drug into the atherosclerotic plaque, without background fluorescence of the vessel wall after vehicle control injection into hypercholesterolemic Ldlr mice. has not independently confirmed the accuracy of these methods. They are for reference only.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Ternant D, et al. Pharmacokinetics and concentration-effect relationship of adalimumab in rheumatoid arthritis. Br J Clin Pharmacol. 2015 Feb;79(2):286-97. [2]. Oberoi R, et al. Targeting Tumor Necrosis Factor-α with Adalimumab: Effects on Endothelial Activation and Monocyte Adhesion. PLoS One. 2016 Jul 28;11(7):e0160145.

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