(D-Trp12,Tyr34)-pTH (7-34) amide (bovine)|118102-98-0|-陌孚医药/Medlife

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(D-Trp12,Tyr34)-pTH (7-34) amide (bovine)

目录号: PL11899 纯度: ≥99%

CAS No. :118102-98-0

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中文名称	(D-Trp12,Tyr34)-pTH (7-34) amide (bovine)
中文别名	L-苯丙氨酰-L-蛋氨酰-L-组氨酰-L-天冬氨酰胺酰-L-亮氨酰-D-色氨酰-L-赖氨酰-L-组氨酰-L-亮氨酰-L-丝氨酰-L-丝氨酰-L-蛋氨酰-L-alpha-谷氨酰-L-精氨酰-L-缬氨酰-L-alpha-谷氨酰-L-色氨酰-L-亮氨酰-L-精氨酰-L-赖氨酰-L-赖氨酰-L-亮氨酰-L-谷氨酰胺酰-L-alpha-天冬氨酰-L-缬氨酰-L-组氨酰-L-天冬氨酰胺酰-L-酪氨酰胺;甲状腺激素相关肽[D-TRP12,TYR34]-PTH (7-34) AMIDE (BOVINE)
英文名称	(D-Trp12,Tyr34)-pTH (7-34) amide (bovine)
英文别名	L-Tyrosinamide,L-phenylalanyl-L-methionyl-L-histidyl-L-asparaginyl-L-leucyl-D-tryptophyl-L-lysyl-L-histidyl-L-leucyl-L-seryl-L-seryl-L-methionyl-L-a-glutamyl-L-arginyl-L-valyl-L-a-glutamyl-L-tryptophyl-L-leucyl-L-arginyl-L-lysyl-L-lysyl-L-leucyl-L-glutaminyl-L-a-aspartyl-L-valyl-L-histidyl-L-asparaginyl-;(D-Trp??00Tyr??)-pTH(7-34)amide(bovine);L-Tyrosinamide,L-phenylalanyl-L-methionyl-L-histidyl-L-asparaginyl-L-leucyl-D-tryptophyl-L-lys...;L-Tyrosinamide,L-phenylalanyl-L-methionyl-L-histidyl-L-asparaginyl-L-leucyl-D-tryptophyl-L-lysyl-L-histidyl-L-leucyl-L-seryl-;L-Tyrosinamide,L-phenylalanyl-L-methionyl-L-histidyl-L-asparaginyl-L-leucyl-D-tryptophyl-L-lysyl-L-histidyl-L-leucyl-L-seryl-L-seryl-L-methionyl-L-a-glutamyl-L-arginyl-L-valyl-L-a-glutamyl-L-tryptophy;H-Phe-Met-His-Asn-Leu-D-Trp-Lys-His-Leu-Ser-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Tyr-NH2;THYROID, BOVINE;PHE-MET-HIS-ASN-LEU-D-TRP-LYS-HIS-LEU-SER-SER-MET-GLU-ARG-VAL-GLU-TRP-LEU-ARG-LYS-LYS-LEU-GLN-ASP-VAL-HIS-ASN-TYR-NH2;[D-Trp12,Tyr34]-bPTH-(7-34)NH2;(D-TRP12,TYR34)-PTH (7-34) AMIDE (BOVINE);H-PHE-MET-HIS-ASN-LEU-D-TRP-LYS-HIS-LEU-SER-SER-MET-GLU-ARG-VAL-GLU-TRP-LEU-ARG-LYS-LYS-LEU-GLN-ASP-VAL-HIS-ASN-TYR-NH2;(D-Trp12,Tyr34)-pTH (7-34) amide;D-Trp12,Tyr34]-bPTH-(7-34)NH2;(D-Trp12,Tyr34)-pTH (7-34) amide (bovine)
Cas No.	118102-98-0
分子式	C₁₆₅H₂₅₁N₄₉O₄₀S₂
分子量	3625.20
包装储存	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

产品详情	(D-Trp12,Tyr34)-pTH (7-34) amide (bovine) 是一种有效的竞争性甲状旁腺激素 (PTH) 拮抗剂，在牛肾皮质膜中的 K_i 值为 69 nM。(D-Trp12,Tyr34)-pTH (7-34) amide (bovine) 可用于生长发育调节。
生物活性	(D-Trp12,Tyr34)-pTH (7-34) amide (bovine) is a potent and competitive antagonist of parathyroid hormone (PTH), with a K i of 69 nM in bovine renal cortical membrane. (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) can be used for growth and development regulation.
性状	Solid
IC50 & Target[1][2]	Ki: 69 nM (PTH)
体外研究(In Vitro)	(D-Trp12,Tyr34)-pTH (7-34) amide (0.05-10 μM) causes a concentration-dependent inhibition of PTHrP or PTH-stimulated cAMP formation in opossum kidney (OK) cells. (D-Trp12,Tyr34)-pTH (7-34) amide (0.1-10 μM) attenuates inhibition of NapiT promoted by 1 nM of either PTHrP or PTH. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	(D-Trp12,Tyr34)-pTH (7-34) amide (1 mg/mL once, 0.1 mg/mL for 6 h; i.v.) has no significant effect on serum calcium levels in hypercalcemic athymic nude mice bearing a human squamous cell carcinoma of the lung. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
SequenceShortening	FMHNL-{d-Trp}-KHLSSMERVEWLRKKLQDVHNY-NH2
Sequence	Phe-Met-His-Asn-Leu-{d-Trp}-Lys-His-Leu-Ser-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Tyr-NH2
参考文献	[1]. Goldma ME, et, al. A new highly potent parathyroid hormone antagonist: [D-Trp12,Tyr34]bPTH-(7-34)NH2. Endocrinology. 1988 Nov; 123(5): 2597-9. [2]. Pizurki L, et, al. Inhibition by (D-Trp12,Tyr34)bPTH(7-34)amide of PTH and PTHrP effects on Pi transport in renal cells. Am J Physiol. 1990 Aug; 259(2 Pt 2): F389-92.

溶解度数据	In Vitro: H₂O : 25 mg/mL (6.90 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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