pm26TGF-β1 peptide TFA||-陌孚医药/Medlife

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pm26TGF-β1 peptide TFA

目录号: PL11865 纯度: ≥99%

商品编号	规格	价格	会员价
PL11865-5mg	5mg	¥6800.00	请登录
PL11865-10mg	10mg	¥11745.45	请登录
PL11865-50mg	50mg	¥31527.27	请登录
PL11865-100mg	100mg	询价	询价
PL11865-200mg	200mg	询价	询价

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中文名称	pm26TGF-β1 peptide TFA
英文名称	pm26TGF-β1 peptide TFA
包装储存	Sealed storage, away from moisture and lightPowder -80°C 2 years；-20°C 1 year

产品详情	pm26TGF-β1 peptide TFA 是一种模拟人 TGF-β1 分子的肽，并对 TGF-β1 受体具有高亲和力。pm26TGF-β1 peptide TFA 具有有效的抗炎特性，并且不表现出嗜中性粒细胞的趋化性。
生物活性	pm26TGF-β1 TFA peptide is a peptide that mimics a portion of the human TGF-β1 molecule. pm26TGF-β1 peptide TFA shows high affinity for the TGF-β1 receptor. pm26TGF-β1 peptide TFA displays potent anti-inflammatory properties and does not exhibit neutrophils’ chemoattraction.
性状	Solid
IC50 & Target[1][2]	TGF-β1 receptor
体外研究(In Vitro)	The synthetic pm26TGF-β1 peptide (1 μM, 10 μM and 100 μM; 24-48 hours) tested in peripheral blood mononuclear cells (PBMC) significantly down-modulates TNF-α and up-regulates IL-10 responses in an inflammatory microenvironment, leading to regulatory T cells (Treg) phenotype differentiation. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	pm26TGF-β1 peptide (100-1000 μg/kg; subcutaneous injection; once; male C57BL/6 mice) treatment decreases neutrophils migration during inflammatory process in C57BL/6 mice. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisture and lightPowder -80°C 2 years；-20°C 1 year
SequenceShortening	ACESPLKRQCGGGS
Sequence	Ala-Cys-Glu-Ser-Pro-Leu-Lys-Arg-Gln-Cys-Gly-Gly-Gly-Ser
参考文献	[1]. Emília R Vaz, et al. A Short Peptide That Mimics the Binding Domain of TGF-β1 Presents Potent Anti-Inflammatory Activity. PLoS One. 2015 Aug 27;10(8):e0136116. [2]. Rodrigues, Tamiris Sabrina. Evaluation of the action of the synthetic peptide pm26TGF-β1, human TGF-β1 mimetic, on TNF-α induced apoptosis in Drosophila melanogaster. Universidade Federal de Uberlandia, 2017.

溶解度数据	In Vitro: H₂O : 100 mg/mL (66.38 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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