(R)-Morinidazole 是一种口服有效的 5-硝基咪唑抗菌剂，在人体中通过 N⁺-葡萄糖醛酸化和磺化进行代谢。(R)-Morinidazole 可用于用于研究细菌感染，包括厌氧菌引起的阑尾炎、盆腔炎 (PID) 等。

(R)-Morinidazole is an orally active and 5-nitroimidazole antimicrobial agent that undergoes extensive metabolism in humans via N-glucuronidation and sulfation. (R)-Morinidazole can be used for bacterial infections research including appendicitis and pelvic inflammatory disease (PID) caused by anaerobic bacteria.

Solid

organic anion transporter

(R)-Morinidazole can be metabolized to N-glucuronide of S-Morinidazole R enantiomer [M8-1] and N-glucuronide of (R)-Morinidazole [M8-2] via N-glucuronidation, and sulfate conjugate of (R)-Morinidazole [M7] via sulfation.
M7 is a substrate for organic anion transporter 1 (OAT1) and OAT3 (Km=28.6 and 54.0 μM, respectively), M8-1 and M8-2 are the substrates for OAT3.
(R)-Morinidazole shows activity against Trichomonas vaginalis and Entamoeba histolytica in vitro, with MIC values of 2 μg/mL and 3 μg/mL, respectively.
has not independently confirmed the accuracy of these methods. They are for reference only.

(R)-Morinidazole (20 mg/kg or 25 mg/kg; p.o.; single dose) inhibits Trichomonas vaginalis and Entamoeba histolytica in vivo in rats with EC 50 s of 20 mg/kg and 25 mg/kg, respectively.
(R)-Morinidazole (50 mg/kg; i.v.; 0.25, 0.75, 1.5 h) shows a different concentration in tissues after intravenous injection, with a higher concentration in liver, kidney, plasma than lung, heart, and spleen in mice.
Pharmacokinetic parameters of (R)-Morinidazole in control and 5/6 nephrectomized (Nx) rats
Group

Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years；4°C 2 years

[1]. Zhong K, et al. Effects of renal impairment on the pharmacokinetics of morinidazole: uptake transporter-mediated renal clearanceof the conjugated metabolites. Antimicrob Agents Chemother. 2014 Jul;58(7):4153-61.
[2]. Kong F, et al. Increased Plasma Exposures of Conjugated Metabolites of Morinidazole in Renal Failure Patients: A Critical Role of Uremic Toxins. Drug Metab Dispos. 2017 Jun;45(6):593-603. 

In Vitro: DMSO : ≥ 100 mg/mL (369.97 mM)配制储备液