Argatroban monohydrate|141396-28-3|(阿加曲班一水合物; MD-805 monohydrate; MCI-9038 monohydrate; Argipidine monohydrate)-陌孚医药/Medlife

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Argatroban monohydrate (Synonyms: 阿加曲班一水合物; MD-805 monohydrate; MCI-9038 monohydrate; Argipidine monohydrate)

目录号: PL11877 纯度: ≥99%

CAS No. :141396-28-3

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中文名称	Argatroban monohydrate
中文别名	阿加曲班;(2R,4R)-4-甲基-1-[N-[(3-甲基-1,2,3,4-四氢-8-喹啉基)磺酰]-L-精氨酰]-2-哌啶甲酸;(2R,4R)-1-[(2S)-5-(氨基亚氨甲基)氨基-1-氧代-2-[(3-甲基-1,2,3,4-四氢喹啉-8-基)磺酰胺基]戊烷]-4-甲基哌啶-2-甲酸;阿加曲班单水合物;Argatroban Monohydrate 阿加曲班单水合物;R)-(-)-N-(二苯亚甲基)甘氨酰左旋樟脑磺内酰胺;阿加曲班 USP标准品;阿加曲班水合物;阿加曲班一水合物
英文名称	Argatroban monohydrate
英文别名	Argatroban;(2R,4R)-4-Methyl-1-[Nalpha-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl)sulfonyl]-L-arginyl]-2-piperidinecarboxylic acid;(2r,4r)-4-methyl-1-[n-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl)sulfonyl]-l-arginyl]-2-piperidinecarboxylic acid;GN1600;(2R,4R)-1-[N2-3-(methyl-1,2,3,4-tetrahydro-8-quinolinesulfonyl)-L-arginyl]-4-methyl-2-piperidinecarboxylic acid monohydrate;(2R,4R)-1-[(2S)-5-[(Aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecarboxylic acid;Argatroban Monohydrate;argatroban hydrate;Argipidine monohydrate;Argipidine;MQPA;Argatroban (monohydrate);Acova;Argatroban [USAN];C23H36N6O5S.H2O;Slonnon;Argatroban (USAN);Argatroban Injection;Argatroban In Sodium Chloride;2-Piperidinecarboxylic acid, 1-(5-((aminoiminomethyl)amino)-1-oxo-2-(((1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl)amino)pentyl)-4-methyl-, monohydrate;2-Piperidinecarboxylic acid, 1-(5-((aminoiminomethyl)amino)-1-oxo-2-(((1,2,3,4-tetrahydro-3-methy;(2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]pentanoyl]-4-methylpiperidine-2-carboxylic acid;hydrate;Argatra;Exembol;Novastan;Argatroban [USAN:INN:BAN:JAN];Novastan (TN);Argatroban (USP);(2R,4R)-1-[(2S)-5-[(Aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,;(2R,4R)-1-[(2S)-5-[(Aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecarboxylic Acid;Argatroban monohydrate
Cas No.	141396-28-3
分子式	C₂₃H₃₈N₆O₆S
分子量	526.65
包装储存	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

产品详情

Argatroban (monohydrate) (MD-805 (monohydrate)) 是 thrombin 选择性抑制剂。

生物活性

Argatroban (monohydrate) (MD-805 (monohydrate)) is a direct, selective thrombin inhibitor.

性状

Solid

IC50 & Target[1][2]

Thrombin.

体外研究(In Vitro)

Argatroban (MD-805) may have a complementary effect for preventing thrombus formation without aggravating bleeding tendency because of its monotarget specificity to thrombin. Administration (0.5 to 2 micrograms/kg/min) of Argatroban (MD-805) is a safe anticoagulant for left heart bypass in repairs of traumatic aortic rupture associated with multiple organ injuries. Argatroban (MD-805), as compared with heparin, appears to enhance reperfusion with TPA in patients with AMI, particularly in those patients with delayed presentation. The incidences of major bleeding and adverse clinical outcome were lower in the patients receiving argatroban. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

ClinicalTrial

参考文献

[1]. Kawada, T., et al., Argatroban, an attractive anticoagulant, for left heart bypass with centrifugal pump for repair of traumatic aortic rupture. Jpn J Thorac Cardiovasc Surg, 1999. 47(3): p. 104-9.
[2]. Jang, I.K., et al., A multicenter, randomized study of argatroban versus heparin as adjunct to tissue plasminogen activator (TPA) in acute myocardial infarction: myocardial infarction with novastan and TPA (MINT) study. J Am Coll Cardiol, 1999. 33(7): p.

溶解度数据	In Vitro: DMSO : ≥ 100 mg/mL (189.88 mM)H₂O : < 0.1 mg/mL (insoluble)

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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