Hydrocortisone hemisuccinate|2203-97-6|(氢化可的松琥珀酸酯; Hydrocortisone 21-hemisuccinate)-陌孚医药/Medlife

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Hydrocortisone hemisuccinate (Synonyms: 氢化可的松琥珀酸酯; Hydrocortisone 21-hemisuccinate)

目录号: PL11825 纯度: ≥98%

CAS No. :2203-97-6

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中文名称	Hydrocortisone hemisuccinate
中文别名	氢可琥珀酸酯;氢化可的松半瑚珀酸酯;氢化可的松琥珀酸酯;* 氢化可的松琥珀酸酯;琥珀酸氢化可的松;柠檬酸铁;氢化可的松琥珀单酯;氢化可的松琥珀酸单酯;氢化可的松琥珀酸脂;氢化可的松琥珀酸酯,CP2005, EP, BP;氢可琥珀酸酯标准品(JP)
英文名称	Hydrocortisone hemisuccinate
英文别名	hydrocortisone 21-hemisuccinate*free acid;hydrocortisone 21-(hydrogen succinate);Hydrocortisone Hemisuccinate;11b,17a,21-Trihydroxy-4-pregnene-3,20-dione 21-hemisuccinate;Hydrocortisone hydrogen succinate;Hydrocortisone 21-hemisuccinate;Hydrocortisone succinate;CORTISOL 21-HEMISUCCINATE;CORTISOL HEMISUCCINATE;cortisol,hydrogensuccinate;cortisolsuccinate;Hydrocortisone 21-he;hydrocortisone hemisuccinate ester;hydrocortisone-21-O-hemisuccinate;Hydrocortizone Succinate;saxizon;Hydrocortisone hemisuccinate
Cas No.	2203-97-6
分子式	C₂₅H₃₄O₈
分子量	462.53
包装储存	Powder -20°C 3 years；In solvent -80°C 6 months

产品详情

Hydrocortisone hemisuccinate (Hydrocortisone 21-hemisuccinate)，一种糖皮质激素，是口服活性的甾体抗炎剂 (SAID)。Hydrocortisone hemisuccinate 抑制 IL-6 和 IL-3 的生物活性，IC₅₀ 值分别为 6.7 和 21.4 μM。Hydrocortisone hemisuccinate 可用于溃疡性结肠炎 (UC) 的研究。

生物活性

Hydrocortisone hemisuccinate (Hydrocortisone 21-hemisuccinate), a physiological glucocorticoid, is an orally active steroidal anti-in?ammatory drug (SAID). Hydrocortisone hemisuccinate inhibits proinflammatory cytokine activity, with IC 50 s of 6.7 and 21.4 μM for IL-6 and IL-3, respectively. Hydrocortisone hemisuccinate can be used for the research of ulcerative colitis (UC).

性状

Solid

IC50 & Target[1][2]

IL-3 IL-6

体外研究(In Vitro)

Hydrocortisone hemisuccinate inhibits IL-6 and IL-3 bioactivity, with IC50s of 6.7 and 21.4 μM, respectively, and shows no cytotoxic effects on IL-6-independent MH60 cells.
Hydrocortisone hemisuccinate (0.12-60 μM; 72 h) inhibits phytohemagglutinin (PHA) response in peripheral lymphocytes (PBL) and T-lymphocytes cultures. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Hydrocortisone hemisuccinate (30 mg/kg; p.o. twice daily for 5 d) reduces the weight loss and increases the food intake in mice. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；In solvent -80°C 6 months

ClinicalTrial

参考文献

[1]. Kang BS, et, al. Inhibitory effects of anti-inflammatory drugs on interleukin-6 bioactivity. Biol Pharm Bull. 2001 Jun;24(6):701-3.
[2]. You YC, et, al. In vitro and in vivo application of pH-sensitive colon-targeting polysaccharide hydrogel used for ulcerative colitis therapy. Carbohydr Polym. 2015 Oct 5;130:243-53.

溶解度数据	In Vitro: DMSO : 250 mg/mL (540.51 mM; Need ultrasonic)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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