AdipoRon|924416-43-3|-陌孚医药/Medlife

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AdipoRon

目录号: PL11807 纯度: ≥99%

CAS No. :924416-43-3

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中文名称	AdipoRon
中文别名	2-(4-苯甲酰基苯氧基)-N-(1-苄基哌啶-4-基)乙酰胺;2-(4-苯甲酰苯氧基)-N-[1-(苯基甲基)-4-哌啶基]乙酰胺;AdipoRon 抑制剂
英文名称	AdipoRon
英文别名	AdipoRon;2-(4-Benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide;Acetamide, 2-(4-benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]-;SC-396658;2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]-acetamide;AdipoR agonist;AdipoRon hydrochloride;2-(4-Benzyoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamidehydrochloride;2-(4-Benzyoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide hydrochloride;ND7UVH6GKJ;2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide;C27H28N2O3;Acetamide,2-(4-benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]-;2-(4-Benzoylphenoxy)-N-(1-(phenylmethyl)-4-piperidinyl)acetamide;AMPD00101;HMS3653C18;BCP08895;ZLB41643;2197AH;BDBM50059083;s7365;STL507766;AM85966;MCULE
Cas No.	924416-43-3
分子式	C₂₇H₂₈N₂O₃
分子量	428.52
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	AdipoRon 是可口服的脂联素受体 (AdipoR) 激动剂，能够与 AdipoR1 和 AdipoR2 结合，K_d 值分别为 1.8 μM 和 3.1 μM。
生物活性	AdipoRon is an orally active adiponectin receptor (AdipoR) agonist, binding to AdipoR1 and AdipoR2 with K d s of 1.8 and 3.1 μM, respectively.
性状	Solid
IC50 & Target[1][2]	Kd: 1.8 μM (AdipoR1), 3.1 μM (AdipoR2)
体外研究(In Vitro)	AdipoRon is an orally active and specific AdipoR agonist, binds to AdipoR1 and AdipoR2, with Kds of 1.8 and 3.1 μM. AdipoRon (50 nM-50 μM) increases AMPK phosphorylation via AdipoR1. AdipoRon (50 μM) dose-dependently attenuates the expression of TNF-α and TGF-β1 in the L02 cells. AdipoRon exhibits significant and dosage-dependent growth suppression on macrophages. AdipoRon treatment significantly improves cardiac functional recovery after reperfusion, and inhibits post-MI apoptosis. AdipoRon exerts vasodilation by mechanisms distinct to adiponectin and induces vasorelaxation without a marked decrease in VSMC [Ca]i. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	AdipoRon (50?mg/kg, i.v.) cuases significant phosphorylation of AMPK in skeletal muscle and liver of wild-type mice but not Adipor1?Adipor2 double-knockout mice. AdipoRon (0.02, 0.1, and 0.5 mg/kg, i.g.) alleviates D-GalN induced hepatotoxicity in mice, and prevents hepatic architecture distortion against D-GalN challenge. The hepatoprotective potential of AdipoRon is particularly evident in higher dosages (0.1 and 0.5 mg/kg). Enhanced cardiomyocyte apoptosis in APN-deficient mice is rescued by AdipoRon (50 mg/kg, p.o.) administration. Antiapoptotic effect of AdipoRon is attenuated but not lost in AMPK-DN mice. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Okada-Iwabu M, et al. A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature. 2013 Nov 28;503(7477):493-9. [2]. Wang Y, et al. Hepatoprotective effects of AdipoRon against d-galactosamine-induced liver injury in mice. Eur J Pharm Sci. 2016 Aug 9;93:123-131. [3]. Zhang Y, et al. Ad

溶解度数据	In Vitro: DMSO : 62.5 mg/mL (145.85 mM; Need ultrasonic)H₂O : < 0.1 mg/mL (insoluble)配制储备液

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