C-176|314054-00-7|-陌孚医药/Medlife

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C-176

目录号: PL11538 纯度: ≥99%

CAS No. :314054-00-7

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中文名称	C-176
中文别名	N-(4-碘苯基)-5-硝基呋喃-2-甲酰胺
英文名称	C-176
英文别名	N-(4-iodophenyl)-5-nitro-2-furamide;2-Furancarboxamide, N-(4-iodophenyl)-5-nitro-;N-(4-Iodophényl)-5-nitro-2-furamide;N-(4-Iodphenyl)-5-nitro-2-furamid;5-Nitro-furan-2-carboxylic acid (4-iodo-phenyl)-amide;BS-16912;C 176;c11h7in2o4;C-176;N-(4-iodophenyl)(5-nitro(2-furyl))carboxamide;N-(4-iodophenyl)-5-nitro-2-furancarboxamide;N-(4-iodophenyl)-5-nitrofuran-2-carboxamide
Cas No.	314054-00-7
分子式	C₁₁H₇In₂O₄
分子量	358.09
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	C-176 是干扰素基因刺激受体 (STING) 的强效共价抑制剂。
生物活性	C-176 is a strong and covalent mouse STING inhibitor.
性状	Solid
IC50 & Target[1][2]	STING.
体外研究(In Vitro)	C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. Pretreatment with C-176 markedly reduce the CMA-mediated induction of serum levels of type I IFNs and IL-6. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	C-176 (750/375 nmol C-176 per mouse in 200 μL corn oil) significantly reduces the CMA-mediated induction of serum levels of type I IFNs and IL-6., without significant toxicity. C-176 results in a significant reduction in serum levels of type I IFNs and in a strong suppression of inflammatory parameters in the heart, with no evident signs of overt toxicity Trex1 mice. C-176 demonstrates marked amelioration of various signs of systemic inflammation in Trex1 mice. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Haag SM, et al. Targeting STING with covalent small-molecule inhibitors. Nature. 2018 Jul;559(7713):269-273.

溶解度数据	In Vitro: DMSO : 62.5 mg/mL (174.54 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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