Diprotin A TFA|209248-71-5|(Ile-Pro-Ile TFA)-陌孚医药/Medlife

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Diprotin A TFA (Synonyms: Ile-Pro-Ile TFA)

目录号: PL11664 纯度: ≥99%

CAS No. :209248-71-5

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中文名称	Diprotin A TFA
中文别名	化合物 T11049
英文名称	Diprotin A TFA
英文别名	Diprotin A TFA;Diprotin A TFA (Synonyms: Ile-Pro-Pro (TFA));Diprotin A TFA (Ile-Pro-Pro (TFA));Ile-Pro-Pro (TFA);Ile-Pro-Ile TFA
Cas No.	209248-71-5
分子式	C₁₉H₃₂F₃N₃O₆
分子量	455.47
包装储存	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

产品详情	Diprotin A TFA (Ile-Pro-Ile TFA) 是二肽基肽酶 IV (DPP-IV) 的抑制剂。
生物活性	Diprotin A TFA (Ile-Pro-Ile TFA) is an inhibitor of dipeptidyl peptidase IV (DPP-IV).
性状	Solid
IC50 & Target[1][2]	DPP-IV.
体外研究(In Vitro)	Diprotin A increases the phosphorylation of Src and vascular endothelial-cadherin (VE-cadherin) in human endothelial cells and disrupts endothelial cell-to-cell junctions, which are attenuated by CXCR4 (receptor of SDF-1α)-blocker or Src-inhibitor. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	In the model of retinopathy of prematurity, Diprotin A increases not only retinal vascularity but also leakage. Additionally, in the murine diabetic retinopathy model, Diprotin A increases the phosphorylation of Src and VE-cadherin and aggravates vascular leakage in the retinas. Collectively, Diprotin A induces vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
参考文献	[1]. Lee CS, et al. Dipeptidyl Peptidase-4 Inhibitor Increases Vascular Leakage in Retina through VE-cadherin Phosphorylation. Sci Rep. 2016 Jul 6;6:29393.

溶解度数据	In Vitro: H₂O : ≥ 77.5 mg/mL (170.15 mM)配制储备液

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