Fostamatinib Disodium|1025687-58-4|(福他替尼二钠盐; R788(Disodium))-陌孚医药/Medlife

您当前的位置：

Fostamatinib Disodium (Synonyms: 福他替尼二钠盐; R788(Disodium))

目录号: PL11555 纯度: ≥99%

CAS No. :1025687-58-4

商品编号	规格	价格	会员价
PL11555-5mg	5mg	¥1236.36	请登录
PL11555-10mg	10mg	¥1978.18	请登录
PL11555-50mg	50mg	¥5563.64	请登录
PL11555-100mg	100mg	¥9272.73	请登录
PL11555-200mg	200mg	询价	询价
PL11555-500mg	500mg	询价	询价
PL11555-10mM*1mLinDMSO	10mM*1mLinDMSO	¥1698.76	请登录

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	Fostamatinib Disodium
中文别名	6-[[5-氟-2-[(3,4,5-三甲氧基苯基)氨基]-4-嘧啶基]氨基]-2;R788 (Fostamatinib) Disodium 抑制剂;6-[[5-氟-2-[(3,4,5-三甲氧基苯基)氨基]-4-嘧啶基]氨基]-2,2-二甲基-4-[(膦酰氧基)甲基]-2H-吡啶并[3,2-B]-1,4-恶嗪-3(4H)-酮钠盐;FOSTAMATINIB 二钠盐;福他替尼（R788）钠盐;福他替尼二钠盐
英文名称	Fostamatinib Disodium
英文别名	R935788;R788 (Fostamatinib) Disodium;Disodium (6-(5-fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-ylamino)-2,2-dimethyl-3-oxo-2H-pyrido[3,2-b][1,4]oxazin-4(3H)-yl)methyl dihydrogen phosphate;disodium,[6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-3-oxopyrido[3,2-b][1,4]oxazin-4-yl]methyl phosphate;Fostamatinib disodium;R 788 Sodium Salt;R788;R788 Sodium;R788(Fostamatinib disodium);R788, Fostamatinib;R788(prodrug of R406);R788,FosD,tamatinib fosdium;FOSTAMATINIB;R 935788 sodium;6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-4-[(phosphonooxy)methyl]-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one sodium salt;FosD;R788 disodium;Tamatinib Fosdium;R788 (sodium salt);FostaMatinib sodiuM;R788(prodrug of R46);R 788 sodium;R935788 (Fostamatinib disodium, R788);X9417132K8;Fostamatinib/R788;Tube731;sodium (6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl)methyl phosphate;C23H24FN6O9P2Na;Fostamatinib Disodium
Cas No.	1025687-58-4
分子式	C₂₃H₂₄FN₆Na₂O₉P
分子量	624.42
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情

Fostamatinib Disodium (R788 Disodium) 是 R406 的口服前药。R406 是一种有效的，具有口服活性的，ATP 竞争性的 Syk/FLT3 抑制剂，K_i 为 30 nM，IC₅₀ 为 41 nM。R406 还抑制 Lyn (IC₅₀=63 nM) 和 Lck (IC₅₀=37 nM).

生物活性

Fostamatinib Disodium (R788 Disodium) is the oral prodrug of the active compound R406. R406 is an orally available and competitive Syk/FLT3 inhibitor with a K i of 30 nM and an IC 50 of 41 nM. R406 also inhibits Lyn (IC 50 =63 nM) and Lck (IC 50 =37 nM).

性状

Solid

IC50 & Target[1][2]

Syk, FLT3

体内研究(In Vivo)

Fostamatinib (R788) is highly bioavailable, and rapidly absorbed in Louvain rats. R406 following a single oral dose of R788 10 mg/kg or 20 mg/kg: AUC 0-16 hrs = 10618 ng*h/mL and 30650 ng*h/mL respectively; C max =2600 ng/mL and 6500 ng/mL respectively (observed at 1 hour); t 1/2 =4.2 hours. The prodrug was not detected in plasma suggesting R788 is completely converted to R406. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. Stephen P McAdoo, et al. Fostamatinib Disodium. Drugs Future. 2011;36(4):273.
[2]. Sylvia Braselmann, et al. R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation. J Pharmacol Exp Ther. 2006 Dec;319(3):998-1008.
[3]. Hoon-Suk Cha

溶解度数据	In Vitro: DMSO : 20.83 mg/mL (33.36 mM; ultrasonic and warming and heat to 60°C)H₂O : ≥ 1 mg/mL (1.60 mM)

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品

The molarity calculator equation

The dilution calculator equation