JNJ-DGAT2-A 是一种选择性、剂量依赖的二酰基甘油酰基转移酶 2 (DGAT2) 抑制剂，在表达人 DGAT2 的 Sf9 昆虫细胞膜中 IC₅₀ 值为 0.14 μM。JNJ-DGAT2-A 可用于甘油三酯 (TG) 合成的研究。

JNJ-DGAT2-A is a selective diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC 50 value of 0.14 μM in human DGAT2-expressing Sf9 insect cell membranes. JNJ-DGAT2-A can be used for the research of triglyceride (TG) synthesis.

Solid

IC50: 0.14 μM (Sf9 insect cell membranes DGAT2)

JNJ-DGAT2-A (5 μM) inhibits about 99% of recombinant DGAT2 enzymatic activity.
JNJ-DGAT2-A (5 μM) inhibits the DGAT activity in HepG2 cell lysates.
JNJ-DGAT2-A (0.3125, 0.625, 1.25, 2.5, 5, 10, and 20 μM; 60 min prior to isotope-labeled and additional 2 h after isotope-labeled) dose-dependently inhibits the generation of TG (52:2), TG (54:3), and TG (50:2) using C3-D5-glycerol as a substrate in HepG2 cells with IC50 values of 0.85 μM, 0.99 μM, and 0.66 μM, respectively.
has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

[1]. Qi J, et al. The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2. J Lipid Res. 2012 Jun;53(6):1106-16.

In Vitro: DMSO : 3.33 mg/mL (6.36 mM; ultrasonic and warming and heat to 60°C)配制储备液