diABZI STING agonist-1|2138299-33-7|-陌孚医药/Medlife

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diABZI STING agonist-1

目录号: PL11521 纯度: ≥99%

CAS No. :2138299-33-7

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中文名称	diABZI STING agonist-1
英文名称	diABZI STING agonist-1
英文别名	diABZI STING agonist-1;STING agonist 3;diABZI STING agonist-1 (Tautomerism);Tautomerism;diABZI STING agonist-3;STING agonist compound 3;L7DUG75C36;GTPL10128;diABZI STING agonist(compound 3);diABZI STING agonist-1 Tautomerism;s8796;diABZI STING agonist 1 (compound 3);(E)-1-(4-(5-Carbamoyl-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-(3-morpholinopropoxy)-1H-benzo[d]imidazol-1-yl)but-2-en-1-
Cas No.	2138299-33-7
分子式	C₄₂H₅₁N₁₃O₇
分子量	849.94
包装储存	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

产品详情	diABZI STING agonist-1 是一个选择性的干扰素基因刺激受体 (STING) 的激动剂，其在人和小鼠中的 EC₅₀ 值分别为 130 nM 和 186 nM。
生物活性	diABZI STING agonist-1 is a selective stimulator of interferon genes (STING) receptor agonist, with EC 50 s of 130, 186 nM for human and mouse, respectively.
性状	Solid
IC50 & Target[1][2]	STING.
体外研究(In Vitro)	diABZI STING agonist-1 is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. At a concentration of 1 μM, diABZI STING agonist-1 (compound 3) demonstrates high selectivity against more than 350 kinases tested. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	diABZI STING agonist-1 (subcutaneous injection; 2.5 mg/kg) induces STING-dependent activation of type-I interferon and pro-inflammatory cytokines in vivo. diABZI STING agonist-1 (intravenous injection; 3 mg/kg) exhibits systemic exposure with a half-life of 1.4 h and achieves systemic concentrations greater than the half-maximal effective concentration (EC 50 ) for mouse STING (200 ng/ml). diABZI STING agonist-1 (intravenous injection; 1.5 mg/kg; days 1, 4 and 8; 43 days) results in significant tumour growth inhibition and significantly improves survival (P?<?0.001) with 8 out of 10 mice remaining tumor free at the end of the study on day 43. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献	[1]. Ramanjulu JM, et al. Design of amidobenzimidazole STING receptor agonists with systemic activity. Nature. 2018 Nov 7.

溶解度数据	In Vitro: DMSO : 100 mg/mL (117.66 mM; Need ultrasonic)配制储备液

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