LQZ-7I|195822-23-2|-陌孚医药/Medlife

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LQZ-7I

目录号: PL11544 纯度: ≥99%

CAS No. :195822-23-2

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中文名称	LQZ-7I
英文名称	LQZ-7I
英文别名	LQZ-7I;N2,N3-bis(4-fluorophenyl)quinoxaline-2,3-diamine;N,N'-bis(4-fluorophenyl)quinoxaline-2,3-diamine;2-N,3-N-bis(4-fluorophenyl)quinoxaline-2,3-diamine;ChemDiv3_003976;HMS1484E16;STL432531;IDI1_021886;D81692;2,3-Quinoxalinediamine, N,N'-bis(4-fluorophenyl)-
Cas No.	195822-23-2
分子式	C₂₀H₁₄F₂N₄
分子量	348.35
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	LQZ-7I 是一种靶向 survivin 的抑制剂。LQZ-7I 抑制生存素二聚化。LQZ-7I 口服有效抑制异种移植肿瘤生长并诱导肿瘤中生存素的损失。
生物活性	LQZ-7I is a survivin-targeting inhibitor. LQZ-7I inhibits survivin dimerization. LQZ-7I orally effectively inhibits xenograft tumor growth and induces survivin loss in tumors.
性状	Solid
IC50 & Target[1][2]	Survivin
体外研究(In Vitro)	LQZ-7I has improved cytotoxicity with IC50s of 3.1 μM against C4-2 cells and 4.8 μM against PC-3 cells compared with the parent compound LQZ-7. LQZ-7I (10 μM; 0-6 hours) treatment reduces the expression of survivin. However, LQZ-7I does not reduce the expression of XIAP, CIAP1, and CIAP2. LQZ-7I may be selective to its intended target survivin. has not independently confirmed the accuracy of these methods. They are for reference only.Weste
体内研究(In Vivo)	LQZ-7I (100 mg/kg; oral gavage every other day for a total of ten treatments) significantly suppresses tumor growth without any notable adverse effect on the mice. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Robert Peery,et al. Synthesis and Identification of a Novel Lead Targeting Survivin Dimerization for Proteasome-Dependent Degradation. J Med Chem. 2020 Jun 9.

溶解度数据	In Vitro: DMSO : 125 mg/mL (358.83 mM; Need ultrasonic)配制储备液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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