MST-312 (Synonyms: Telomerase Inhibitor IX)
目录号: PL11580 纯度: ≥98%
CAS No. :368449-04-1
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中文名称
MST-312
英文名称
MST-312
英文别名
Mst-312;MST-312 (TELOMERASE INHIBITOR IX);N-[3-[(2,3-dihydroxybenzoyl)amino]phenyl]-2,3-dihydroxybenzamide;N,N′-1,3-Phenylenebis-[2,3-dihydroxy-benzamide];MST-312
Cas No.
368449-04-1
分子式
C20H16N2O6
分子量
380.35
包装储存
Powder -20°C 3 years;4°C 2 years
产品详情
MST-312 是一个 telomerase 抑制剂。MST-312 是绿茶表没食子儿茶素没食子酸酯 (EGCG) 的化学修饰衍生物。MST-312 可用于肿瘤的研究,如多发性骨髓瘤 (MM)。
生物活性
MST-312 is a telomerase inhibitor. MST-312 is a chemically modified derivative of green tea epigallocatechin gallate (EGCG). MST-312 can be used for the research of cancer, such as multiple myeloma (MM).
性状
Solid
IC50 & Target[1][2]
telomeras
体外研究(In Vitro)
MST-312 (2~8 μM; 0~72 hours; U-266 cells) reduces cellular viability in a dose dependent and time-dependent manner.
MST-312 (2~8 μM; 48 hours; U-266 cells) induces cell apoptosis in a dose-dependent manner.
MST-312 (2 μM; 48 hours; U-266 cells) up-regulates the pro-apoptotic gene Bax and down-regulates the anti-apoptotic gene Bcl-2 and suppresses the expression of c-Myc and hTERT genes. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years;4°C 2 years
参考文献
[1]. Ameri Z, et al. Telomerase inhibitor MST-312 induces apoptosis of multiple myeloma cells and down-regulation of anti-apoptotic, proliferative and inflammatory genes. Life Sci. 2019;228:66-71.
溶解度数据
In Vitro: DMSO : 75 mg/mL (197.19 mM; ultrasonic and warming and heat to 60°C)配制储备液
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1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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