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| 商品编号 | 规格 | 价格 | 会员价 | 是否有货 | 数量 |
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| PL11504-5mg | 5mg | ¥989.09 | 请登录 |
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| PL11504-10mg | 10mg | ¥1730.91 | 请登录 |
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| PL11504-25mg | 25mg | ¥3585.45 | 请登录 |
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| PL11504-50mg | 50mg | 询价 | 询价 |
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| PL11504-100mg | 100mg | 询价 | 询价 |
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| PL11504-10mM*1mLinDMSO | 10mM*1mLinDMSO | ¥1528.15 | 请登录 |
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| 中文名称 |
Icomidocholic acid
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|---|---|
| 英文名称 |
Icomidocholic acid
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| 英文别名 |
(4R)-4-[(3S,5S,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-dihydroxy-3-(icosanoylamino)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic aci;(4R)-4-[(3S,5S,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-dihydroxy-3-(icosanoylamino)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid;(3beta,5beta,7alpha,12alpha)-7,12-Dihydroxy-3-[(1-oxoeicosyl)amino]cholan-24-oic acid;(3beta)-Arachidylamido-7alpha,12alpha-dihydroxy-5beta-cholan-24-oic acid;C20-FABAC;Aramchol
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| Cas No. |
246529-22-6
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| 分子式 |
C44H79NO5
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| 分子量 |
702.10
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| 包装储存 |
Powder -20°C 3 years；In solvent -80°C 6 months
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| 产品详情 |
Icomidocholic acid (Aramchol) 是胆酸和花生酸的结合物，抑制硬脂酰辅酶 A 去饱和酶 1 (SCD1) 的活性。Icomidocholic acid 在非酒精性脂肪性肝病 (NAFLD) 和非酒精性脂肪性肝炎 (NASH) 中具有潜在的应用潜能。
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| 生物活性 |
Icomidocholic acid (Aramchol) is a conjugate of cholic acid and arachidic acid that could inhibit stearoyl coenzyme A desaturase 1 (SCD1) activity. Icomidocholic acid has potential use in nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) treatment.
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| 性状 |
Solid
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
Powder -20°C 3 years；In solvent -80°C 6 months
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| ClinicalTrial |
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| 参考文献 |
[1]. Safadi R, et al. The fatty acid-bile acid conjugate Aramchol reduces liver fat content in patients with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. 2014 Dec;12(12):2085-91.e1.[2]. Iruarrizaga-Lejarreta M, et al. Role of Aramchol in steatohepatitis and fibrosis in mice. Hepatol Commun. 2017 Nov;1(9):911-927.
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| 溶解度数据 |
In Vitro: DMSO : 25 mg/mL (35.61 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)配制储备液
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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。
2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。
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