YTX-465 是一种硬脂酰辅酶 A 去饱和酶 (Ole1/SCD) 抑制剂。YTX-465 抑制 Ole1 和 SCD1的 IC₅₀ 值分别为 0.039 μM 和 30.4 μM。YTX-465 可用于帕金森病和其他突触核蛋白病的研究。

YTX-465 is a stearoyl-CoA desaturase (Ole1/SCD) inhibitor. YTX-465 inhibits Ole1 and SCD1 with IC 50 s of 0.039 μM and 30.4 μM, respectively. YTX-465 can be used in the research of Parkinson’s disease and other synucleinopathies.

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Ole1 0.039 μM (IC50) SCD1 30.4 μM (IC

YTX-465 (1-10000 nM) has an EC50 value of 0.013 μM for α-synuclein (α-syn) toxicity rescue.
YTX-465 (0.05 μM; 0-2 days) rescue the growth of α-Syn-expressing yeast.
YTX-465 (0, 10, 40, 160, 640, 2500 nM; 4h) increases the level of Ole1 protein in wild-type yeast expressing OLE1 in a concentration-dependent manner, that indicate YTX-465 induce a negative feedback loop.
YTX-465 (0, 0.03, 0.09, 0.27, 0.81 μM; 6 hours) reduces fatty desaturation in a concentration-dependent manner in wild-type yeast, with a 50% reduction in desaturation at 0.03 μM.
YTX-465 (0.25 μM; 8 hours) decreases the desaturation index (DI) for all major classes of membrane phospholipids in wild-type yeast. has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature in continental US; may vary elsewhere.

4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

[1]. Vincent BM, et al. Inhibiting Stearoyl-CoA Desaturase Ameliorates α-Synuclein Cytotoxicity. Cell Rep. 2018 Dec 4;25(10):2742-2754.e31.

In Vitro: DMSO : 100 mg/mL (218.10 mM; Need ultrasonic)配制储备液