RRD-251|72214-67-6|-陌孚医药/Medlife

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RRD-251

目录号: PL10770 纯度: ≥99%

CAS No. :72214-67-6

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中文名称	RRD-251
中文别名	(2,4-二氯苯基)甲基硫基甲烷脒盐酸盐
英文名称	RRD-251
英文别名	RRD-251 hydrochloride;(2,4-dichlorophenyl)methyl carbamimidothioate,hydrochloride;2,4-Dichlorobenzyl imidothiocarbamate hydrochloride;(2,4-dichlorophenyl)methylisothiourea hydrochloride;2-(2,4,6-Trimethylbenzyl)-2-thiopseudoharnstoff-hydrochlorid;NSC181936;S-(2,4,6-Trimethyl-benzyl)-isothioharnstoff, Hydrochlorid;S-(2,4,6-trimethyl-benzyl)-isothiourea, hydrochloride;S-(2,4-Dichlor-benzyl)-isothioharnstoff, Hydrochlorid;S-(2,4-dichlorobenzyl)isothiourea hydrochloride;S-(2,4-dichloro-benzyl)-isothiourea, hydrochloride;S-(2.4-Dichlor-benzyl)-isothiuronium-chlorid;(2,4-Dichlorophenyl)carbamimidothioic acid methyl ester hydrochloride;2-(2,4-Dichlorobenzyl)-2-thiopseudourea hydrochloride;S-(2,4-Dichlorobenzyl)-isothiouronium hydrochloride;Raf-1 disruptor 251 hydrochloride;RRD-251;Rb/Raf-1 disruptor 251 hydrochloride
Cas No.	72214-67-6
分子式	C₈H₉Cl₃N₂S
分子量	271.59
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	RRD-251 是一种视网膜母细胞瘤肿瘤抑制蛋白 (Rb)-Raf-1相互作用 (Rb-Raf-1 interaction) 的抑制剂，具有高效的抗增殖、抗血管生成和抗肿瘤活性。
生物活性	RRD-251 is an inhibitor of retinoblastoma tumor suppressor protein (Rb)-Raf-1 interaction, with potent anti-proliferative, anti-angiogenic and anti-tumor activities.
性状	Solid
IC50 & Target[1][2]	Rb-Raf-1 interaction, apoptosis
体外研究(In Vitro)	RRD-251 (10-50 μM; 24 hours) inhibits melanoma growth in-vitro. RRD-251 (50 μM; 2 hours) inhibits Rb-Raf-1 interaction and Rb phosphorylation in non-small cell lung cancer cells. RRD-251 induces apoptosis (50 μM; 18 hours) and cell cycle arrest (20-50 μM; 4 hours). RRD-251 alters the expression of cell cycle and apoptosis regulatory protein. has not independently confirmed the accuracy of these methods. They are for reference only.Cell Pr
体内研究(In Vivo)	RRD-251 (50 mg/kg; i.p.; q.o.d; for 14 days) has anti-cancer activities in vivo on melanomas. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 8-wk-old female athymic nude mice
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Sandeep Singh, et al. Rb-Raf-1 interaction disruptor RRD-251 induces apoptosis in metastatic melanoma cells and synergizes with dacarbazine. Mol Cancer Ther. 2010 Dec; 9(12): 3330–3341.

溶解度数据	In Vitro: DMSO : 125 mg/mL (460.25 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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