Dapoxetine hydrochloride|129938-20-1|(盐酸达泊西汀; LY-210448 hydrochloride)-陌孚医药/Medlife

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Dapoxetine hydrochloride (Synonyms: 盐酸达泊西汀; LY-210448 hydrochloride)

目录号: PL11258 纯度: ≥99%

CAS No. :129938-20-1

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中文名称	Dapoxetine hydrochloride
中文别名	盐酸达泊西汀;达泊西汀盐酸盐 ((S)-(+)-N,N-二甲基-3-(1-萘氧基)苯丙胺盐酸盐);达泊西汀盐酸盐;(S)-N,N-二甲基-3-(萘基-1-氧基)--1-苯基丙-1-胺盐酸盐;达泊西汀;混旋达泊西汀;盐酸达泊西汀（右旋）;盐酸达泊西汀标准品;盐酸达泊西汀左旋;右旋达泊西汀;右旋达泊西汀盐酸盐;(S)-N,N-二甲基-3-(1-萘氧基)-1-苯丙胺盐酸盐;(S)-N,N-二甲基-α-[2-(1-萘氧基)乙基]苯甲胺盐酸盐;达泊西汀盐酸盐（混旋）;达莫西汀;盐酸达波西汀;盐酸盐;酸达泊西汀;达泊西汀混旋;右旋盐酸达泊西汀;达莫西汀盐酸盐;达泊西汀杂质11;盐酸达泊西汀;盐酸达泊西汀右旋
英文名称	Dapoxetine hydrochloride
英文别名	Dapoxetine hydrochloride;DAPOXETINE HCL;Rimonabant 75000;LY-21044;((S)-(+)-N,N-Dimethyl-1-phenyl-3-(1-naphthalenyloxy)propanamine hydrochloride);(S-(+)-N,N-dimethyl-a-[2-(naphthalenyloxy)ethyl] benzenemethanamine hydrochloride;(1S)-N,N-Dimethyl-3-naphthalen-1-yloxy-1-phenyl-propan-1-amine hydrochloride;(S)-n,n-dimethyl-3-(naphthalene-1-yloxy)-1-phenylpropan-1-amine hydrochloride;(S)-N,N-Dimethyl-3-(naphthalen-1-yloxy)-1-phenylpropan-1-amine hydrochloride;DL-Dapoxteine HCL;LY-210448 hydrochloride;S-(+)-N,N-Dimethyl-a-[2-(naphthalenyloxy)ethyl]benzenemethanamine hydrochloride;(1S)-N,N-dimethyl-3-naphthalen-1-yloxy-1-phenylpropan-1-amine,hydrochloride;(S)-N,N-Dimethyl-3-(1-naphthyloxy)-1-phenylpropylamine Hydrochloride;(S)-N,N-Dimethyl-α-[2-(1-naphthyloxy)ethyl]benzylamine Hydrochloride;(S)-N,N-dimethyl-1-phenyl-3-(1-naphthalenyloxy)propanamine hydrochloride;S-(+)-N,N-dimethyl-a-[2-(naphthalenyloxy)ethyl] benzenemethanamine hydrochloride, LY-210448 hydrochloride;LY-210448;Mixed spin Dapoxetine;Dapoxetine hcl for R&D;Dapoxetine Impurity 11;(S)-Dapoxetine hydrochloride
Cas No.	129938-20-1
分子式	C₂₁H₂₃NO^.HCl
分子量	341.88
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情

Dapoxetine (LY-210448) hydrochloride 是一种具有口服活性的选择性血清素再摄取 (serotonin reuptake) 抑制剂 (SSRI)。Dapoxetine hydrochloride 可用于早泄 (PE) 的相关研究。

生物活性

Dapoxetine (LY-210448) hydrochloride is an orally active and selective serotonin reuptake inhibitor (SSRI). Dapoxetine hydrochloride can be used for the research of premature ejaculation (PE).

性状

Solid

IC50 & Target[1][2]

Target: serotonin reuptake

体外研究(In Vitro)

Dapoxetine hydrochloride binds to 5-HT, norepinephrine, and dopamine reuptake transporters and inhibits 5-HT, norepinephrine, and dopamine uptake with an order of potency: 5-HT >norepinephrine?dopamine.
Dapoxetine hydrochloride inhibits the uptake of [H]5-HT by the 5-HT reuptake transporter with a value of 1.12 nM, and Dapoxetine inhibits the uptake of [H]norepinephrine into cells utilizing the norepinephrine reuptake transporter and uptake of [H]dopamine by the dopamine reuptake transporter with IC50 values of 202 nM and 1720 nM, respectively.
has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Dapoxetine hydrochloride (oral gavage; 1-10 mg/kg; once daily) significantly inhibits testosterone mediated increase in the prostate weight and relative prostate weight and attenuates testosterone-induced prostatic hyperplasia in rats.
has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. Muammer Kendirci, et al. Dapoxetine, a novel selective serotonin transport inhibitor for the treatment of premature ejaculation. Ther Clin Risk Manag. 2007 Jun;3(2):277-89.
[2]. Rabab H Sayed, et al. Dapoxetine attenuates testosterone-induced prostatic hyperplasia in rats by the regulation of inflammatory and apoptotic proteins. Toxicol Appl Pharmacol. 2016 Nov 15;311:52-60.

溶解度数据	In Vitro: H₂O : 100 mg/mL (292.51 mM; Need ultrasonic)DMSO : ≥ 32 mg/mL (93.60 mM)

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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