Benzocaine|94-09-7|-陌孚医药/Medlife

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Benzocaine

目录号: PL11372 纯度: ≥99%

CAS No. :94-09-7

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中文名称	Benzocaine
中文别名	苯佐卡因;苯唑卡因;对氨基苯甲酸乙酯;4-氨基苯甲酸乙酯;胺苯乙酯;PABA乙酯;對胺苯甲酸乙酯;苯卡因;ben佐卡因;Ethyl 4-Aminobenzoate 4-氨基苯甲酸乙酯;WAKO020-15791苯唑卡因标准品;氨基苯甲酸乙酯;苯佐卡因局麻药;苯佐卡因量大从优;苯佐卡因（对氨基苯甲酸乙酯）;苯佐卡因,对氨基苯甲酸乙酯;苯佐卡因200目;苯佐卡因EP7;苯佐卡因标准品;苯佐卡因标准品(JP);苯佐卡因及其杂质对照品;苯佐卡因原药;苯唑卡因,AR;苯唑卡因,Benzocaine;苯唑卡因,GR;苯唑卡因标准品;对氨基苯甲酸乙酯USP36;环戊酮-2-羧酸乙酯;氨苯甲酸乙酯;苯佐卡因(阿奈司台辛,氨苯甲酸乙酯);对氨基苯甲酸乙酯,Ethyl 4-aminobenzoate ,分析标准品;对氨基苯甲酸乙酯、苯佐卡因;局部麻醉药;麻因;乙基-4-氨基苯甲酸酯;乙基4-氨基苯甲酸酯;培美曲塞二钠杂质9
英文名称	Benzocaine
英文别名	Ethyl 4-aminobenzoate;4-AMINOBENZOIC ACID ETHYL ESTER;AETHOFORM;anesthesin;auralgan otic;BENZOCAINE;benzocaine bp98;BENZOCAINUM;ethyl aminobenzoate;ETHYLAMINOBENZOATE-4;ETHYL P-AMINOBENZOATE;H-4-ABZ-OET;LABOTEST-BB LTBB000527;ORTHESIN;P-AMINOBENZOIC ACID ETHYL ESTER;parathesin;4-(Ethoxycarbonyl)aniline;4-amino-benzoicaciethylester;4-Carbethoxyaniline;Benzocaine (See B197952 for Labelled);4-amino-benzoic acid ethyl ester;4-ethoxycarbonylaniline;Anaesthin;Ethoform;ethyl 4-aminobenzene carboxylate;ethyl 4-amino-benzoate;ethyl ester of p-aminobenzoic acid;Euphagin;Norcain;Norcaine;Ora-jel;Solu H;Topcaine;Americaine;Anaesthesin;Amben ethyl ester;p-Carbethoxyaniline;Hurricaine;Parathesine;Dermoplast;Identhesin;Anesthesine;Anestezin;Anesthone;Keloform;Anaesthan-syngala;Solarcaine;p-Ethoxycarboxylic aniline;Baby Anbesol;p-(Ethoxycarbonyl)aniline;Benzoic acid, 4-amin;Benzoic acid, p-amino-, ethyl ester (8CI);(p-(Ethoxycarbonyl)phenylamine;4-(Ethoxycarbonyl)phenylamine;4-Aminobenzoic acid ethyl ester;Aethoform;Anbesol;Anesthesin;Benzoak;Benzocaine;Diet Ayds;Et-PABA;Ethyl aminobenzoate;Ethyl p-aminobenzenecarboxylate;Ethyl p-aminobenzoate;Ethyl p-aminophenylcarboxylate;Gingicaine;MeSH ID: D001566;NSC 41531;NSC 4688;Orabase-B;Orthesin;p-Aminobenzoic acid ethyl ester;Parathesin;Slim Mint Gum;4-Aminobenzoic Acid Ethyl Ester;Benzocaine BP98;Auralgan Otic
Cas No.	94-09-7
分子式	C₉H₁₁NO₂
分子量	165.19
包装储存	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

产品详情

Benzocaine 作用电压门控Na⁺通道的共同受体，其在 +30 mV 下测得的 IC₅₀ 值为0.8 mM。

生物活性

Benzocaine shares a common receptor with all othe rLAs in the voltage-gated Na channel, with an IC 50 of 0.8 mM tested with a potential of +30 mV.

性状

Solid

IC50 & Target[1][2]

IC50: 0.8 mM (Na channel).

体外研究(In Vitro)

Benzocaine blocks μ1 wild-type Na currents in a dose-dependent Manner. The Benzocaine concentration that inhibits 50% of Na currents (IC50) is estimated to be about 0.8 mM when a test potential of +30 mV is applied. The slope of the h∞ curve is also significantly reduced by benzocaine (from 6.6 to 9.9 mV). Mutation of μ1-N1584A also significantly increases the potency of Benzocaine. At 1 mM, Benzocaine blocks about 55% of wild-type Na current but about 95% of μ1-N1584A mutant current. Benzocaine also appears to bind more strongly to its LA receptor in the N1584A mutant than in the wild type. The inhibition of Ca uptake occurres at lower Benzocaine concentration (IC50=40.3±1.2mM) than that affecting the enzymatic activity. has not independently confirmed the accuracy of these methods. They are for r

体内研究(In Vivo)

Benzocaine is topically applied to the following species: dogs, domestic shorthair cats, Long-Evans rats, Sprague-Dawley rats, ferrets, rhesus monkeys, cynomolgus monkeys, owl monkeys, New Zealand White rabbits, miniature pigs, ICR mice, C3H mice, and C57BL/10SnJ mice. All animals, except mice and rats, receive a 2-second spray to the mucous membranes of the nasopharynx for an estimated dose of 56 mg. A 2-second spray to rodents oral mucous membranes delivers too great a volume of fluid for these animals. The study is repeated in dogs several months later to confirm low response. Response to Benzocaine spray is observed in most animals tested, with response peaking between 15 and 30 minutes after dosing. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

ClinicalTrial

参考文献

[1]. Wang GK et al. A common local anesthetic receptor for benzocaine and etidocaine in voltage-gated mu1 Na+ channels. Pflugers Arch. 1998 Jan;435(2):293-302.
[2]. Davis JA, et al. Benzocaine-induced methemoglobinemia attributed to topical application of the anesthetic in several laboratory animal species. Am J Vet Res. 1993 Aug;54(8):1322-6.

溶解度数据	In Vitro: DMSO : ≥ 100 mg/mL (605.36 mM)H₂O : 2 mg/mL (12.11 mM; ultrasonic and warming and heat to 60°C)

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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