Citalopram hydrobromide|59729-32-7|(氢溴酸西酞普兰; (±)-Citalopram hydrobromide; Lu 10-171)-陌孚医药/Medlife

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Citalopram hydrobromide (Synonyms: 氢溴酸西酞普兰; (±)-Citalopram hydrobromide; Lu 10-171)

目录号: PL11260 纯度: ≥99%

CAS No. :59729-32-7

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中文名称	Citalopram hydrobromide
中文别名	喜普妙;1-(3-二甲氨丙基)-1-(4-氟代苯基)-1,3-二氢异苯并呋喃-5-腈,氢溴酸盐;1-[3-(二甲氨基)丙基]-1-(4-氟苯基)-1,3-二氢-5-异苯并呋喃甲腈氢溴酸盐;氢溴酸西肽普兰;氢溴酸西酞;西酞普兰氢溴酸盐;西酞普兰氢溴酸;氢溴酸西酞普兰;氢溴酸西酞普兰 EP标准品;氢溴酸西酞普兰 USP标准品;氢溴酸西酞普兰标准品;西酞普兰;西酞普兰系统适应性 EP标准品;艾司西酞普兰-a09;氢溴酸氰肽氟苯胺
英文名称	Citalopram hydrobromide
英文别名	1-(3-(Dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile hydrobromide;5-ISOBENZOFURANCARBONITRILE, 1,3-DIHYDRO-1-(3-(DIMETHYLAMINO)PROPYL)-1-(4-FLUOROPHENYL)-;CITALOPRAM HBR;(+/-)-CITALOPRAM HYDROBROMIDE;5-isobenzofurancarbonitrile,1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3;Citalopram Hydrobromide Tablets;1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile monohydrobromide;Citalopram (hydrobromide);Citalopram hydrobromide solution;Citalopram, Hydrobromide Salt;(¡À)-Citalopram hydrobromide;(±)-Citalopram hydrobromide;Citalopram;Lu 10-171;Lu 10-171B;1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile hydrobromide;Citalopram hydrobromide;1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile Hydrobromide;Cipramil;Celexa;Seropram;Elopram;Bonitrile HBr;Nitalapram HBr;Prepram HBr;Citalopram hydrobromide [USAN];CPD000326936;Cit
Cas No.	59729-32-7
分子式	C₂₀H₂₂BrFN₂O
分子量	405.30
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情

Citalopram hydrobromide 是一种选择性血清素再摄取抑制剂 (SSRI)。 Citalopram hydrobromide 抑制 5-HT 摄取进入突触体，IC₅₀ 为 1.8 nM。 Citalopram hydrobromide 抑制兔血小板中 5-HT 的摄取，IC₅₀ 为 14 nM。具有抗抑郁作用。

生物活性

Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI). Citalopram hydrobromide inhibits 5-HT uptake into synaptosomes with an IC 50 of 1.8 nM. Citalopram hydrobromideinhibits the 5-HT uptake in rabbit blood platelets with an IC 50 of 14 nM. Antidepressant effect.

性状

Solid

体外研究(In Vitro)

Citalopram（25-150 μM) shows a concentration-dependent cytotoxicity on the viability of rat B104, human SH-SY5Y, IMR32 and Kelly neuroblastoma cell lines and human primary Schwann cells (HSC). has not independently confirmed the accuracy of these methods. They are for reference only.Cell Viability Assay

体内研究(In Vivo)

Acute administration of Citalopram (1-10 mg/kg, i.p. 1 h before an elevated plus-maze test) to Spontaneously Hypertensive rats (SHRs), Lewis (LEW) rats, and Wistar-Kyoto (WKY) rats, i.e., rat strains differing for their emotionality, promotes anxiety, and/or hypoactivity, except in WKY rats. In the three strains, such a pretreatment increased central 5-HT levels and/or decreased 5-hydroxyindoleacetic acid levels. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. J Hyttel. Citalopram--pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity. Prog Neuropsychopharmacol Biol Psychiatry. 1982;6(3):277-95.
[2]. Laurent Sakka, et al. Assessment of citalopram and escitalopram on neuroblastoma cell lines. Cell toxicity and gene modulation. Oncotarget. 2017 Jun 27;8(26):42789-42807.

溶解度数据	In Vitro: DMSO : ≥ 38 mg/mL (93.76 mM)H₂O : 10 mg/mL (24.67 mM; Need ultrasonic)

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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