SPHINX
目录号: PL11451 纯度: ≥99%
CAS No. :848057-98-7
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中文名称
SPHINX
英文名称
SPHINX
英文别名
SPHINX;5-methyl-N-(2-morpholino-5-(trifluoromethyl)phenyl)furan-2-carboxamide;US9695160, SPHINX;BDBM221070;5-methyl-N-[2-morpholin-4-yl-5-(trifluoromethyl)phenyl]furan-2-carboxamide;5-Methyl-N-[2-(4-morpholinyl)-5-(trifluoromethyl)phenyl]-2-furamide
Cas No.
848057-98-7
分子式
C17H17F3N2O3
分子量
354.32
包装储存
Powder -20°C 3 years;4°C 2 years
产品详情
SPHINX 是 SRPK1 的选择性抑制剂,IC50 值为 0.58 μM。SPHINX 有效地减少体内脉络膜新生血管 (CNV)。SPHINX 可用于老年性黄斑变性的研究。
生物活性
SPHINX is a selective SRPK1 inhibitor with an IC 50 value of 0.58 μM. SPHINX effectively reduces Choroidal Neovascularization (CNV) in vivo. SPHINX can be used for the research of (age-related macular degenaration) AMD.
性状
Solid
IC50 & Target[1][2]
IC50: 0.58 μM (SRPK1)
体外研究(In Vitro)
SPHINX (10 μM; 2 h) affects EGF-induced phosphorylation of SRSF1 and SRSF2.
SPHINX (5 μM; 24 h) reduces the expression of VEGF165 relative to GAPDH control either in primary RPE and ARPE-19 cell lines. has not independently confirmed the accuracy of these methods. They are for reference only.Western Blot Analysis
体内研究(In Vivo)
SPHINX (10 ng; i.o. on laser photocoagulation day 0 and day 7) affects neovascular growth in vivo.
SPHINX (25 ng; i.o. on laser photocoagulation day 0 and day 7) affects the CNV area in CNV rats. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years;4°C 2 years
ClinicalTrial
参考文献
[1]. Gammons MV, et al. Topical antiangiogenic SRPK1 inhibitors reduce choroidal neovascularization in rodent models of exudative AMD. Invest Ophthalmol Vis Sci. 2013 Sep 5;54(9):6052-62.
溶解度数据
In Vitro: DMSO : 50 mg/mL (141.12 mM; ultrasonic and warming and heat to 60°C)配制储备液
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1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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