SRPIN340|218156-96-8|(SRPK inhibitor)-陌孚医药/Medlife

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SRPIN340 (Synonyms: SRPK inhibitor)

目录号: PL11453 纯度: ≥99%

CAS No. :218156-96-8

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中文名称	SRPIN340
中文别名	N-(2-(哌啶-1-基)-5-(三氟甲基)苯基)异烟酰胺;N-(2-(1-哌啶基)-5-(三氟甲基)苯基)-4-吡啶甲酰胺;N-[2-(1-哌啶基)-5-(三氟甲基)苯基]-4-吡啶甲酰胺;SRPIN 340 抑制剂
英文名称	SRPIN340
英文别名	N-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide;di-n-propyl squarate;SR protein phosphorylation inhibitor 1;3-Cyclobutene-1,2-dione, 3,4-dipropoxy-;CTK2D3599;1,2-di-n-propoxy-cyclobutenedione;squaric acid dibutyl ester;3,4-Dipropoxy-3-cyclobuten-1,2-dion;4-Pyridinecarboxamide, N-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]-;N-(2-(Piperidin-1-yl)-5-(trifluoromethyl)phenyl)isonicotinamide;SRPIN 340;SRPK inhibitor;(SRPIN)340 N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide;3-Cyclobutene-1,2-dione,3,4-dipropoxy;4-Pyridinecarboxamide (N-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl];SRPIN-340;(SRPIN)340;N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide;SRPIN340;N-[2-(Piperidin-1-yl)-5-(trifluoromethyl)phenyl]pyridine-4-carboxamide;C18H18F3N3O;N-[2-piperidin-1-yl-5-(trifluoromethyl)phenyl]pyridine-4-carboxamide;AOB1635;SYN5233;DWFGGOFPIIS
Cas No.	218156-96-8
分子式	C₁₈H₁₈F₃N₃O
分子量	349.35
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	SRPIN340 是一种 ATP 竞争性的 SRPK抑制剂，能够抑制 SRPK1 的活性，K_i 值为 0.89 μM。
生物活性	SRPIN340 is an ATP-competitive serine-arginine-rich protein kinase (SRPK) inhibitor, with a K i of 0.89 μM for SRPK1.
性状	Solid
IC50 & Target[1][2]	Ki: 0.89 μM (SRPK1)
体外研究(In Vitro)	SRPIN340 is a serine-arginine-rich protein kinase (SRPK) inhibitor, with a Ki of 0.89 μM for SRPK1. SRPIN340 also inhibits SRPK2, but shows no significant inhibition on other SRPK, such as Clk1 and Clk4. SRPIN340 promotes degradation of SRp75, which is necessary for HIV expression. SRPIN340 suppresses the propagation of Sindbis virus (IC50, 60 μM) as well as severe acute respiratory syndrome virus. SRPIN340 shows inhibitory effect on leukemia cell lines, such as AML HL60, ALL-T Molt4 and Jurkat, with IC50s of 44.7 μM, 92.2 μM and 82.3 μM, respectively. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Fukuhara T, et al. Utilization of host SR protein kinases and RNA-splicing machinery during viral replication. Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11329-33. [2]. Siqueira RP, et al. Potential Antileukemia Effect and Structural Analyses of SRPK Inhibition by N-(2-(Piperidin-1-yl)-5-(Trifluoromethyl)Phenyl)Isonicotinamide (SRPIN340). PLoS One. 2015 Aug 5;10(8):e0134882.

溶解度数据	In Vitro: DMSO : ≥ 42 mg/mL (120.22 mM)配制储备液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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