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| 中文名称 |
Angiopeptin TFA
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|---|---|
| 中文别名 |
血管抑肽三氟乙酸盐
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| 英文名称 |
Angiopeptin TFA
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| 英文别名 |
Angiopeptin TFA
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| Cas No. |
2478421-60-0
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| 分子式 |
C59H74F6N10O14S2
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| 分子量 |
1325.40
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| 包装储存 |
Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
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| 产品详情 |
Angiopeptin TFA 是生长抑素的环状八肽类似物，是一种 sst2/sst5 受体部分激动剂，IC50 值分别为 0.26 nM 和 6.92 nM。Angiopeptin TFA 可以抑制生长激素释放和胰岛素样生长因子-1 (IGF-1) 产生。Angiopeptin TFA 抑制腺苷酸环化酶或刺激细胞外酸化。Angiopeptin TFA 具有用于冠状动脉粥样硬化研究的潜力。
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|---|---|
| 生物活性 |
Angiopeptin TFA, a cyclic octapeptide analogue of somatostatin, is a weak sst 2 /sst 5 receptor partial agonist with IC 50 values of 0.26?nM and 6.92?nM, respectively. Angiopeptin TFA is a potent inhibitor of growth hormone release and insulin-like growth factor-1 (IGF-1) production. Angiopeptin TFA inhibits adenylate cyclase or stimulates extracellular acidification. Angiopeptin TFA has the potential for coronary atherosclerosis research.
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| 性状 |
Solid
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| IC50 & Target[1][2] |
IC50: 0.26?nM (sst2) and 6.92?nM (sst5)
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| 体外研究(In Vitro) |
Angiopeptin (0.1 nM- 10 μM; for 1?h) TFA acts as a partial agonist (pEC50=6.57) with a maximum response of 423% at 3?μM on the release of tritium on CHO hsst2 cells. has not independently confirmed the accuracy of these methods. They are for reference only.
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| 体内研究(In Vivo) |
Angiopeptin (20 and 50μg/kg; i.h.) TFA significantly inhibits neointimal formation.
Angiopeptin (20 μg/kg; per day) TFA significantly inhibits coronary artery myointimal proliferation in cardiac allografts by appmximalely 50%. has not independently confirmed the accuracy of these methods. They are for reference only.
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
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| SequenceShortening |
{Nal}CYWKVCT-NH2
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| 参考文献 |
[1]. Lundergan CF, et al. Peptide inhibition of myointimal proliferation by angiopeptin, a somatostatin analogue. J Am Coll Cardiol. 1991;17(6 Suppl B):132B-136B.[2]. Alderton F, et al. Somatostatin receptor-mediated arachidonic acid mobilization: evidence for partial agonism of synthetic peptides. Br J Pharmacol. 2001;132(3):760-766.
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| 溶解度数据 |
In Vitro: H2O : 10 mg/mL (7.54 mM; Need ultrasonic)配制储备液
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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。
2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。
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