AFM-30a hydrochloride||-陌孚医药/Medlife

您当前的位置：

AFM-30a hydrochloride

目录号: PL10740 纯度: ≥99%

商品编号	规格	价格	会员价
PL10740-1mg	1mg	¥2967.27	请登录
PL10740-5mg	5mg	¥9198.55	请登录
PL10740-10mg	10mg	¥14539.64	请登录
PL10740-50mg	50mg	询价	询价
PL10740-100mg	100mg	询价	询价

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	AFM-30a hydrochloride
英文名称	AFM-30a hydrochloride
包装储存	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

产品详情	AFM-30a hydrochloride 是一种有效的蛋白质精氨酸脱亚胺酶 2 (PAD2) 抑制剂，具有出色的 PAD2 选择性。AFM-30a hydrochloride 与 PAD2 结合的 EC₅₀ 值为 9.5 μM。AFM-30a hydrochloride 还抑制 H3 瓜氨酸化，EC₅₀ 值为 0.4 μM。AFM-30a hydrochloride 可用于某些癌症和多种自身免疫性疾病如类风湿性关节炎 (RA)、多发性硬化症、狼疮和溃疡性结肠炎的研究。
生物活性	AFM-30a hydrochloride is a potent protein arginine deiminase 2 (PAD2) inhibitor and has excellent PAD2-selectivity. AFM-30a hydrochloride binds to PAD2 with an EC 50 value of 9.5 μM. AFM-30a hydrochloride also inhibits H3 citrullination with an EC 50 value of 0.4 μM. AFM-30a hydrochloride can be used for the research of certain cancers and a variety of autoimmune diseases including rheumatoid arthritis (RA), multiple sclerosis, lupus, and ulcerative colitis.
性状	Solid
IC50 & Target[1][2]	EC50: 9.5 μM (PAD2); 0.4 μM (H3 citrullination)
体外研究(In Vitro)	AFM-30a hydrochloride (compound 30a; 25 μM) has good potency to enter HEK293T/PAD2 cells and covalent modify PAD2 with an EC50 of 9.5 μM. AFM-30a hydrochloride shows good ability to inhibit H3 citrullination with an EC50 of 0.4 μM. has not independently confirmed the accuracy of these methods. They are for reference only.Cell Viability Assay
体内研究(In Vivo)	AFM-30a hydrochloride suppresses NLRP3 signaling and decreases airway remodeling in PAD2transgenic mice. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献	[1]. Aaron Muth, et al. Development of a Selective Inhibitor of Protein Arginine Deiminase 2. J Med Chem. 2017 Apr 13;60(7):3198-3211. [2]. R. Surolia, et al. Role of PAD2 Regulated Inflammasome Signaling in Arsenic Induced Airway Inflammation and Remodeling. American Journal of Respiratory and Critical Care Medicine 2020;201:A2976.

溶解度数据	In Vitro: H₂O : 50 mg/mL (99.41 mM; Need ultrasonic)DMSO : 50 mg/mL (99.41 mM; ultrasonic and warming and heat to 60°C)配制储备液

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品

The molarity calculator equation

The dilution calculator equation