Clomipramine-d6 (hydrochloride)|1189882-28-7|(Chlorimipramine-d-陌孚医药/Medlife

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Clomipramine-d6 (hydrochloride) (Synonyms: Chlorimipramine-d

目录号: PL11244

CAS No. :1189882-28-7

商品编号	规格	价格	会员价
PL11244-1mg	1mg	询价	询价
PL11244-10mg	10mg	询价	询价
PL11244-50mg	50mg	询价	询价

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中文名称	Clomipramine-d6 (hydrochloride)
中文别名	[2H6]-盐酸氯米帕明;[2H6]-氯米帕明盐酸盐;CLOMIPRAMINE-D6 HYDROCHLORIDE (N,N-DIMETHYL-D6);氯米帕明-[D6]盐酸盐;盐酸氯米帕明 d6 (盐酸盐)
英文名称	Clomipramine-d6 (hydrochloride)
英文别名	Clomipramine-d6 Hydrochloride;3-Chloro-10,11-dihydro-N,N-(dimethyl-d6)-5H-dibenz[b,f]azepine-5-propanamine Hydrochloride;3-Chloro-5-[3-(dimethylamino-d6)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine Hydrochloride;Anafranil-d6;Chlorimipramine-d6 Hydrochloride;Clomical;Clomicalm-d6;Clomipramine-d6 HCl;Clomipramine-d6 (hydrochloride)
Cas No.	1189882-28-7
分子式	C₁₉H₂₄Cl₂N₂
分子量	351.31
包装储存	Please store the product under the recommended conditions in the Certificate of Analysis.

产品详情	Clomipramine-d₆ (hydrochloride) 是 Clomipramine hydrochloride 的氘代物。Clomipramine (Chlorimipramine) hydrochloride 有效阻断 5-HT 再摄取 (5-HT reuptake)，IC₅₀ 值为 1.5 nM。Clomipramine 是一种三环类抗抑郁药，可用于抑郁症和强迫症（OCD）的研究。
生物活性	Clomipramine-d 6 (hydrochloride) is the deuterium labeled Clomipramine hydrochloride. Clomipramine (Chlorimipramine) hydrochloride is a potent 5-HT reuptake blocker with the IC50 value of 1.5 nM. Clomipramine hydrochloride is a tricyclic antidepressant that can be used for the research of depression and obsessive compulsive disorder (OCD)[1].
体外研究(In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Yumi Sugimoto, et al. The tricyclic antidepressant Clomipramine increases plasma glucose levels of mice. J Pharmacol Sci. 2003 Sep;93(1):74-9. [3]. Mushtaq Ahmed, et al. Com

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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