BIM-23190 hydrochloride||-陌孚医药/Medlife

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BIM-23190 hydrochloride

目录号: PL11410 纯度: ≥98%

商品编号	规格	价格	会员价
PL11410-5mg	5mg	¥4327.27	请登录
PL11410-10mg	10mg	¥7170.91	请登录
PL11410-50mg	50mg	询价	询价
PL11410-100mg	100mg	询价	询价

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

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中文名称	BIM-23190 hydrochloride
英文名称	BIM-23190 hydrochloride
包装储存	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

产品详情	BIM-23190 hydrochloride 是 somatostatin 的类似物，是 SSTR2 和SSTR5 的选择性激动剂，对SSTR2 和SSTR5 的K_i 值分别为 0.34 nM 和 11.1 nM。BIM-23190 可用于糖尿病和癌症研究。
生物活性	BIM-23190 hydrochloride, a somatostatin analog, a selective SSRT2 and SSRT5 agonist, exhibits K i values of 0.34 nM and 11.1 nM for SSTR2 and SSTR5, respectively. BIM-23190 can be used in the study for cancer and acromegaly.
性状	Solid
IC50 & Target[1][2]	SSTR2 SSTR5
体外研究(In Vitro)	BIM-23190 tends to mildly stimulate PRL secretion. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	BIM-23190 (50 μg/mouse, twice a day) exhibits significant anti-tumor (C6 glioma) activity. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male athymic nude (nu/nu) mice, 5-6 wk old (
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
SequenceShortening	{4-(2-Hydroxyethyl)-1-piperazinylacetyl}-{D-Phe}-CY-{D-Trp}-K-{Abu}-CT-NH2 (Disulfide bridge: Cys2-Cys7)
Sequence	{4-(2-Hydroxyethyl)-1-piperazinylacetyl}-{D-Phe}-Cys-Tyr-{D-Trp}-Lys-{Abu}-Cys-Thr-NH2 (Disulfide bridge: Cys2-Cys7)
参考文献	[1]. I Shimon, et al. Somatostatin receptor (SSTR) subtype-selective analogues differentially suppress in vitro growth hormone and prolactin in human pituitary adenomas. Novel potential therapy for functional pituitary tumors. J Clin Invest. 1997 Nov 1;100(9):2386-92. [2]. Federica Barbieri, et al. Differential efficacy of SSTR1, -2, and -5 agonists in the inhibition of C6 glioma growth in nude mice. Am J Physiol Endocrinol Metab. 2009 Nov;297(5):E1078-88.

溶解度数据	In Vitro: DMSO : 100 mg/mL (80.72 mM; Need ultrasonic)H₂O : 100 mg/mL (80.72 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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