CL097|1026249-18-2|-陌孚医药/Medlife

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CL097

目录号: PL10948 纯度: ≥99%

CAS No. :1026249-18-2

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中文名称	CL097
英文名称	CL097
英文别名	CL097;3H-Imidazo[4,5-c]quinolin-4-amine, 2-(ethoxymethyl)-
Cas No.	1026249-18-2
分子式	C₁₃H₁₄N₄O
分子量	242.28
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	CL097 是一种有效的 TLR7 和 TLR8 激动剂，可在巨噬细胞中诱导促炎细胞因子。CL097 诱导 NADPH 氧化酶启动活性，导致 fMLF 刺激的 ROS 产生增加。
生物活性	CL097, a potent TLR7 and TLR8 agonist, induces pro-inflammatory cytokines in macrophages. CL097 induces NADPH oxidase priming, resulting in an increase of the fMLF-stimulated ROS production.
性状	Solid
IC50 & Target[1][2]	TLR7 TLR8
体外研究(In Vitro)	CL097 induces activation of NF-κB at 0.1 μM in TLR7 transfected HEK293 cells and at 4 μM in TLR8-transfected HEK293 cells. CL097 induces hyperactivation of the NADPH oxidase by stimulating the phosphorylation of p47phox on selective sites in human neutrophils and suggest that p38 MAPK, ERK1/2, protein kinase C, and Pin1 control this process. CL097 induces the phosphorylation of p47phox on specific sites and enhances fMLF-induced p47phox phosphorylation. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	CL097 and CD40 agonist stimulation induces efficient diabetogenic Cytotoxic T lymphocyte (CTL) function in NOD mice. CL097 (5 mg/kg, s.c.) alone causes a modest specific lysis of the target peptide (～25%). However, treatment with a combination of CL097 and CD40 agonist (10 mg/kg, i.p.) results in an increase of approximately twofold in the specific lysis of the IGRP-peptide-coated targets compared with CL097 treatment alone. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Cindy Patinote, et al. Agonist and antagonist ligands of toll-like receptors 7 and 8: Ingenious tools for therapeutic purposes. Eur J Med Chem. 2020 May 1;193:112238. [2]. Karama Makni-Maalej, et al. The TLR7/8 agonist CL097 primes N-formyl-methionyl-leucyl-phenylalanine-stimulated NADPH oxidase activation in human neutrophils: critical role of p47phox phosphorylation and the proline isomerase Pin1. J Immunol. 2012 Nov 1;18

溶解度数据	In Vitro: DMSO : 100 mg/mL (412.75 mM; Need ultrasonic)配制储备液

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