Antipain dihydrochloride|37682-72-7|-陌孚医药/Medlife

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Antipain dihydrochloride

目录号: PL11226

CAS No. :37682-72-7

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中文名称	Antipain dihydrochloride
中文别名	2,4-二氯-α-氯甲基苯甲醇;抗蛋白酶;抗痛素二盐酸盐;试剂级
英文名称	Antipain dihydrochloride
英文别名	L-Valinamide,N2-[[[(1S)-1-carboxy-2-phenylethyl]amino]carbonyl]-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-,hydrochloride (1:2);Antipain;ANTIPAIN DIHYDROCHLORIDE;L-Valinamide,N2-[[[(1S)-1-carboxy-2-phenylethyl]amino]carbonyl]-L-arginyl-N-[4-[(aminoiminomet...;L-Valinamide,N2-[[[(1S)-1-carboxy-2-phenylethyl]amino]carbonyl]-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-,hydr;N-(Nα-Carbonyl-Arg-Val-Arg-al)-Phe;PHE-ARG-VAL-ARG-CHO.2HCL;Antipain dihydrochloride from microbial source;N2-[[[(1S)-1-Carboxy-2-phenylethyl]amino]carbonyl]-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-L-valinamide hydrochloride (1:2);Antipain dihydrochloride
Cas No.	37682-72-7
分子式	C₂₇H₄₄N₁₀O₆^.₂[HCl]
分子量	677.62
包装储存	-20°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情

Antipain dihydrochloride是一种从 Actinomycetes 分离的蛋白酶 (protease) 抑制剂。Antipain dihydrochloride 抑制 N-甲基-N'-硝基-N-亚硝基胍 (MNNG) 诱导的转化，增加染色体畸变。Antipain dihydrochloride 限制小鼠中子宫 DNA 合成和功能。

生物活性

Antipain dihydrochloride is a protease inhibitor isolated from Actinomycetes. Antipain dihydrochloride inhibits N-methyl-N-nitro-N-nitrosoguanidine (MNNG)-induced transformation and increases chromosomal aberrations. Antipain dihydrochloride restricts uterine DNA synthesis and function in mice.

性状

Solid

体内研究(In Vivo)

The intact, cycling female mice received subcutaneous injections of Antipain dihydrochloride (3 mg) for 16 days, their uteri shows significant diminution in weight and total DNA when compared to untreated controls.
Antipain dihydrochloride (100 μg/g body wt; i.p.; at 12h intervals from 0 to 120 h or 240 to 360 h) shows inhibitory effect on Urethane-induced lung neoplasia in mice. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. DiPaolo JA, et al. Antipain inhibits N-methyl-N-nitro-N-nitrosoguanidine-induced transformation and increases chromosomal aberrations. Proc Natl Acad Sci U S A. 1980 Nov;77(11):6649-53.
[2]. Suda H,et al. Antipain, a new protease inhibitor isolated from actinomycetes. J Antibiot (Tokyo). 1972 Apr;25(4):263-6.

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Data Sheet

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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