GSK547|2226735-55-1|(GSK'547)-陌孚医药/Medlife

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GSK547 (Synonyms: GSK'547)

目录号: PL11033 纯度: ≥99%

CAS No. :2226735-55-1

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中文名称	GSK547
英文名称	GSK547
英文别名	GSK547
Cas No.	2226735-55-1
分子式	C₂₀H₁₈F₂N₆O
分子量	396.39
包装储存	-20°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

产品详情	GSK547 (GSK'547) 是一种高效的选择性 receptor-interacting serine/threonine protein kinase 1 (RIPK1) 抑制剂，可抑制巨噬细胞介导的胰腺癌适应性免疫耐受。
生物活性	GSK547 (GSK547) is a highly selective and potent inhibitor of receptor-interacting serine/threonine protein kinase 1 (RIPK1), inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer.
性状	Solid
IC50 & Target[1][2]	RIP1
体外研究(In Vitro)	GSK547 (0.1-100000 nM; 24 hours) pretreats L929 cells with recombinant TNFα and zVAD at various doses for 30 min, then cell death is induced with an IC50 of 32 nM after 24 hours. GSK547 up-regulates STAT1 signaling in bone marrow-derived macrophages (BMDM). has not independently confirmed the accuracy of these methods. They are for reference only.Cell Viability Assay
体内研究(In Vivo)	GSK547 (GSK′547; RIP1i) robustly targets RIP1 in vivo. RIP1 inhibition results in immunogenic macrophage differentiation in pancreatic cancer, leading to adaptive immune activation and tumor protection for pancreatic ductal adenocarcinoma (PDA). GSK547 (100 mg/kg/day; fed via food-based dosing; 15-50 days) reduces tumor burden and extends survival compared with mice treated with controls or Nec-1s. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	-20°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
参考文献	[1]. Wang W, et al. RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer. Cancer Cell. 2018 Nov 12;34(5):757-774.e7.

溶解度数据	In Vitro: DMSO : 250 mg/mL (630.69 mM; Need ultrasonic)配制储备液

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