3-Oxo-5β-cholanoic acid|1553-56-6|(Dehydrolithocholic acid; 3-oxoLCA)-陌孚医药/Medlife

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3-Oxo-5β-cholanoic acid (Synonyms: Dehydrolithocholic acid; 3-oxoLCA)

目录号: PL11072 纯度: ≥99%

CAS No. :1553-56-6

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中文名称	3-Oxo-5β-cholanoic acid
中文别名	(5beta)-3-氧代-胆烷-24-酸;1-芘甲基本丙烯酸(甲)酯;3-氧代-5β-胆烷酸
英文名称	3-Oxo-5β-cholanoic acid
英文别名	Cholan-24-oic acid,3-oxo-, (5b)-;3-Oxo-5beta-cholanoic Acid;DEHYDROLITHOCHOLIC ACID;3-Oxo-5β-cholanoic A;3-Oxo-5β-cholanoic Acid;5B-CHOLANIC ACID-3-ONE;3-oxo-5beta-cholanic acid;3-oxocholanic acid;3-Oxo-5b-cholanoic Acid
Cas No.	1553-56-6
分子式	C₂₄H₃₈O₃
分子量	374.56
包装储存	-20°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

产品详情	3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid)，胆汁酸代谢产物，通过直接与关键转录因子RORγt (K_d=1.13 μM) 结合抑制 TH17 细胞分化。
生物活性	3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid), a bile acid metabolite, inhibits the diferentiation of TH17 cells by directly binding to the key transcription factor RORγt (K d =1.13 μM).
性状	Solid
体外研究(In Vitro)	Treatment with 3-Oxo-5β-cholanoic acid significantly reduced the activity of the RORγt reporter. These data suggest that 3-Oxo-5β-cholanoic acid probably inhibits TH17 cell differentiation by physically interacting with RORγt, and inhibiting its transcriptional activity. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (0.3% (w/w); p.o.; for 1 week) significantly reduces the percentage of ileal TH17 cells. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	-20°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
参考文献	[1]. Hang S, et al. Bile acid metabolites control TH17 and Treg cell differentiation. Nature. 2019 Dec;576(7785):143-148.

溶解度数据	In Vitro: DMSO : 4 mg/mL (10.68 mM; Need ultrasonic)配制储备液

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